Institute of Tropical Medicine Antwerp
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Population genetic structure and cladistic analysis of Trypanosoma brucei isolates

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dc.contributor.author Agbo, E. C. en_US
dc.contributor.author Clausen, P. H. en_US
dc.contributor.author Büscher, P. en_US
dc.contributor.author Majiwa, P. A. O. en_US
dc.contributor.author Claassen, E. en_US
dc.contributor.author Te Pas, M. F. W. en_US
dc.date.accessioned 2007-12-06T14:33:07Z
dc.date.available 2007-12-06T14:33:07Z
dc.date.issued 2003 en_US
dc.identifier.issn 1567-1348 en_US
dc.identifier.other ITG-P3A en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-SEROL en_US
dc.identifier.other JIF en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/64
dc.description.abstract Using a novel multilocus DNA marker analysis method, we studied the population genetic structure of Trypansoma brucei stocks and derived clones isolated from animal and rhodesiense sleeping sickness patients during a national sleeping sickness control program in Mukono district, Uganda. We then performed a cladistic analysis to trace relationships and evolution, using stocks and clones recovered from geographically and temporally matched hosts, including inter-strain comparisons with T. b. gambiense stocks and clones. Our results show that while there was close genetic relatedness among parasite populations from the same geographical region, micro-heterogeneities exist between different stocks. Data are presented that indicate that not every human sleeping sickness focus may be associated with a particular human-infective trypanosome strain responsible for long-term stability of the reference focus. We provide evidence of genetic sub-structuring among type 1 T. b. gambiense stocks, which has potentially important implications for molecular epidemiology of T. brucei. en_US
dc.language English en_US
dc.subject Protozoology en_US
dc.subject Trypanosoma brucei en_US
dc.subject Phylogenetics en_US
dc.subject Population genetics en_US
dc.subject Molecular markers en_US
dc.subject Polymorphism en_US
dc.title Population genetic structure and cladistic analysis of Trypanosoma brucei isolates en_US
dc.type Article en_US
dc.citation.jtitle Infection, Genetics and Evolution en_US
dc.citation.volume 3 en_US
dc.citation.pages 165-174 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/14522180
dc.citation.jabbreviation Infect Genet Evol en_US


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