Institute of Tropical Medicine Antwerp
Foundation of Public Utility

Clonal differences between Non-Typhoidal Salmonella (NTS) recovered from children and animals living in close contact in The Gambia

DSpace/Manakin Repository

Show simple item record

dc.contributor.author Dione, M. M.
dc.contributor.author Ikumapayi, U. N.
dc.contributor.author Saha, D.
dc.contributor.author Mohammed, N. I.
dc.contributor.author Geerts, S.
dc.contributor.author Ieven, M.
dc.contributor.author Adegbola, R. A.
dc.contributor.author Antonio, M.
dc.date.accessioned 2011-06-28T13:01:29Z
dc.date.available 2011-06-28T13:01:29Z
dc.date.issued 2011
dc.identifier.issn 1935-2727
dc.identifier.doi http://dx.doi.org/10.1371/journal.pntd.0001148
dc.identifier.other ITG-A1B
dc.identifier.other ITG-A5A
dc.identifier.other ANIMAL
dc.identifier.other U-VPROT
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other Electronic
dc.identifier.other FTA
dc.identifier.other Abstract
dc.identifier.other UPD35
dc.identifier.uri http://hdl.handle.net/10390/6591
dc.description.abstract BACKGROUND: Non-Typhoidal Salmonella (NTS) is an important cause of invasive bacterial disease and associated with mortality in Africa. However, little is known about the environmental reservoirs and predominant modes of transmission. Our study aimed to study the role of domestic animals in the transmission of NTS to humans in rural area of The Gambia. METHODOLOGY: Human NTS isolates were obtained through an active population-based case-control surveillance study designated to determine the aetiology and epidemiology of enteric infections covering 27,567 Gambian children less than five years of age in the surveillance area. Fourteen children infected with NTS were traced back to their family compounds and anal swabs collected from 210 domestic animals present in their households. Identified NTSs were serotyped and genotyped by multi-locus sequencing typing. PRINCIPAL FINDINGS: NTS was identified from 21/210 animal sources in the households of the 14 infected children. Chickens carried NTS more frequently than sheep and goats; 66.6%, 28.6% and 4.8% respectively. The most common NTS serovars were S. Colindale in humans (21.42%) and S. Poona in animals (14.28%). MLST on the 35 NTS revealed four new alleles and 24 sequence types (ST) of which 18 (75%) STs were novel. There was no overlap in serovars or genotypes of NTS recovered from humans or animal sources in the same household. CONCLUSION: Our results do not support the hypothesis that humans and animals in close contact in the same household carry genotypically similar Salmonella serovars. These findings form an important baseline for future studies of transmission of NTS in humans and animals in Africa. en
dc.language English en
dc.subject Bacterial diseases en
dc.subject Zoonoses en
dc.subject Salmonellosis en
dc.subject Salmonella en
dc.subject Reservoirs en
dc.subject Livestock en
dc.subject Domestic animals en
dc.subject Prevalence en
dc.subject Children en
dc.subject Surveillance en
dc.subject Contact tracing en
dc.subject Distance en
dc.subject Serovars en
dc.subject Genotypes en
dc.subject Phenotyping en
dc.subject Genetic diversity en
dc.subject Alleles en
dc.subject Strains en
dc.subject Clinical manifestations en
dc.subject Diarrhea en
dc.subject Drug susceptibility en
dc.subject Antibiotics en
dc.subject Gambia en
dc.subject Africa, West en
dc.title Clonal differences between Non-Typhoidal Salmonella (NTS) recovered from children and animals living in close contact in The Gambia en
dc.type Article-E en
dc.citation.issue 5 en
dc.citation.jtitle PLoS Neglected Tropical Diseases en
dc.citation.volume 5 en
dc.citation.pages e1148 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/21655353
dc.citation.jabbreviation PLoS Negl Trop Dis en


Files in this item

This item appears in the following Collection(s)

Show simple item record