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Population-based biochemistry, immunologic and hematological reference values for adolescents and young adults in a rural population in Western Kenya

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dc.contributor.author Zeh, C.
dc.contributor.author Amornkul, P. N.
dc.contributor.author Inzaule, S.
dc.contributor.author Ondoa, P.
dc.contributor.author Oyaro, B.
dc.contributor.author Mwaengo, D. M.
dc.contributor.author Vandenhoudt, H.
dc.contributor.author Gichangi, A.
dc.contributor.author Williamson, J.
dc.contributor.author Thomas, T.
dc.contributor.author Decock, K. M.
dc.contributor.author Hart, C.
dc.contributor.author Nkengasong, J.
dc.contributor.author Laserson, K.
dc.date.accessioned 2011-08-03T11:58:01Z
dc.date.available 2011-08-03T11:58:01Z
dc.date.issued 2011
dc.identifier.issn 1932-6203
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0021040
dc.identifier.other ITG-M7A
dc.identifier.other MICRO
dc.identifier.other U-HIVSTD
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other FTA
dc.identifier.other Electronic
dc.identifier.other Abstract
dc.identifier.other UPD36
dc.identifier.uri http://hdl.handle.net/10390/6618
dc.description.abstract BACKGROUND: There is need for locally-derived age-specific clinical laboratory reference ranges of healthy Africans in sub-Saharan Africa. Reference values from North American and European populations are being used for African subjects despite previous studies showing significant differences. Our aim was to establish clinical laboratory reference values for African adolescents and young adults that can be used in clinical trials and for patient management. METHODS AND FINDINGS: A panel of 298, HIV-seronegative individuals aged 13-34 years was randomly selected from participants in two population-based cross-sectional surveys assessing HIV prevalence and other sexually transmitted infections in western Kenya. The adolescent (<18 years)-to-adults (>/=18 years) ratio and the male-to-female ratio was 1ratio1. Median and 95% reference ranges were calculated for immunohematological and biochemistry values. Compared with U.S-derived reference ranges, we detected lower hemoglobin (HB), hematocrit (HCT), red blood cells (RBC), mean corpuscular volume (MCV), neutrophil, glucose, and blood urea nitrogen values but elevated eosinophil and total bilirubin values. Significant gender variation was observed in hematological parameters in addition to T-bilirubin and creatinine indices in all age groups, AST in the younger and neutrophil, platelet and CD4 indices among the older age group. Age variation was also observed, mainly in hematological parameters among males. Applying U.S. NIH Division of AIDS (DAIDS) toxicity grading to our results, 40% of otherwise healthy study participants were classified as having an abnormal laboratory parameter (grade 1-4) which would exclude them from participating in clinical trials. CONCLUSION: Hematological and biochemistry reference values from African population differ from those derived from a North American population, showing the need to develop region-specific reference values. Our data also show variations in hematological indices between adolescent and adult males which should be considered when developing reference ranges. This study provides the first locally-derived clinical laboratory reference ranges for adolescents and young adults in western Kenya. en
dc.language English en
dc.subject Viral diseases en
dc.subject HIV en
dc.subject AIDS en
dc.subject Reference values en
dc.subject Adolescents en
dc.subject Adults en
dc.subject Biochemistry en
dc.subject Immunology en
dc.subject Hematology en
dc.subject Clinical trials en
dc.subject Patient care management en
dc.subject Hemoglobin en
dc.subject Hematocrit en
dc.subject Red blood cells en
dc.subject Eosinophiles en
dc.subject Gender distribution en
dc.subject Age distribution en
dc.subject Kenya en
dc.subject Africa, East en
dc.title Population-based biochemistry, immunologic and hematological reference values for adolescents and young adults in a rural population in Western Kenya en
dc.type Article-E en
dc.citation.issue 6 en
dc.citation.jtitle PLoS ONE en
dc.citation.volume 6 en
dc.citation.pages e21040 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/21713038
dc.citation.jabbreviation PLoS ONE en


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