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Virulence in Trypanosoma congolense Savannah subgroup. A comparison between strains and transmission cycles

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dc.contributor.author Van den Bossche, P.
dc.contributor.author Chitanga, S.
dc.contributor.author Masumu, J.
dc.contributor.author Marcotty, T.
dc.contributor.author Delespaux, V.
dc.date.accessioned 2011-08-04T11:25:37Z
dc.date.available 2011-08-04T11:25:37Z
dc.date.issued 2011
dc.identifier.issn 0141-9838
dc.identifier.doi http://dx.doi.org/10.1111/j.1365-3024.2010.01277.x
dc.identifier.other ITG-A1A
dc.identifier.other ITG-A2B
dc.identifier.other ITG-A3B
dc.identifier.other ITG-A4A
dc.identifier.other ITG-ALA
dc.identifier.other ANIMAL
dc.identifier.other U-VCONT
dc.identifier.other U-VPROT
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other Abstract
dc.identifier.other UPD36
dc.identifier.uri http://hdl.handle.net/10390/6639
dc.description.abstract Trypanosoma congolense strains have been shown to differ in their virulence both between subgroups and within the Savannah subgroup between strains. This review revisits these findings and complements them with information on the virulence of T. congolense Savannah subgroup strains isolated from cattle (domestic transmission cycle) in different geographical areas and of strains isolated in protected areas where trypanotolerant wildlife species are the reservoir of the trypanosomes (sylvatic transmission cycle). The virulence of a total of 62 T. congolense Savannah subgroup strains (50 domestic and 12 sylvatic), determined using a standard protocol in mice, was compared. Virulence varied substantially between strains with, depending on the strain, the median survival time of infected mice varying from 5 to more than sixty days. The proportion of highly virulent strains (median survival time < 10 days) was significantly (P = 0.005) higher in strains from the sylvatic transmission cycle. The analysis highlights repercussions of the domestication of the trypanosomiasis transmission cycle that may have to be taken in consideration in the development of trypanosomiasis control strategies. en
dc.language English en
dc.subject Animal diseases en
dc.subject Nagana en
dc.subject Trypanosoma congolense en
dc.subject Cattle en
dc.subject Livestock en
dc.subject Wildlife en
dc.subject Molecular epidemiology en
dc.subject Strains en
dc.subject Transmission dynamics en
dc.subject Virulence en
dc.subject Survival en
dc.subject Review of the literature en
dc.subject Zambia en
dc.subject Africa, Southern en
dc.title Virulence in Trypanosoma congolense Savannah subgroup. A comparison between strains and transmission cycles en
dc.type Article en
dc.citation.issue 8 en
dc.citation.jtitle Parasite Immunology en
dc.citation.volume 33 en
dc.citation.pages 456-460 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/21204855
dc.citation.jabbreviation Parasite Immunol en


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