Institute of Tropical Medicine Antwerp
Foundation of Public Utility

Efflux as mechanism for drug resistance in Mycobacterium tuberculosis

DSpace/Manakin Repository

Show simple item record

dc.contributor.author Almeida da Silva, P. E.
dc.contributor.author Von Groll, A.
dc.contributor.author Martin, A.
dc.contributor.author Palomino, J. C.
dc.date.accessioned 2011-10-05T11:33:23Z
dc.date.available 2011-10-05T11:33:23Z
dc.date.issued 2011
dc.identifier.issn 0928-8244
dc.identifier.doi http://dx.doi.org/10.1111/j.1574-695X.2011.00831.x
dc.identifier.other ITG-M2B
dc.identifier.other ITG-M3A
dc.identifier.other ITG-MLA
dc.identifier.other MICRO
dc.identifier.other U-MYCOB
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other Abstract
dc.identifier.other UPD38
dc.identifier.uri http://hdl.handle.net/10390/6682
dc.description.abstract Tuberculosis (TB) remains an important global public health problem with an estimated prevalence of 14 million people with TB worldwide in 2007. Since antibiotic treatment is one of the main tools for TB control, knowledge of Mycobacterium tuberculosis drug resistance is an important component for the disease control strategy. Although several gene mutations in specific loci of the M. tuberculosis genome have been reported as the basis for drug resistance, additional resistance mechanisms are now believed to exist. Efflux is a ubiquitous mechanism responsible for intrinsic and acquired drug resistance in prokaryotic and eukaryotic cells. M. tuberculosis presents one of the largest numbers of putative drug efflux pumps compared to its genome size. Bioinformatics, as well as direct and indirect evidence have established relationships among drug efflux with intrinsic or acquired resistance in M. tuberculosis. This mini-review describes the current knowledge on drug efflux in M. tuberculosis. en
dc.language English en
dc.subject Bacterial diseases en
dc.subject Tuberculosis en
dc.subject Mycobacterium tuberculosis en
dc.subject Prevalence en
dc.subject Treatment en
dc.subject Antibiotics en
dc.subject Drug resistance en
dc.subject Prokaryotes en
dc.subject Eukaryotic cells en
dc.subject Drug efflux en
dc.subject Virulence en
dc.subject Review of the literature en
dc.title Efflux as mechanism for drug resistance in Mycobacterium tuberculosis en
dc.type Article en
dc.citation.issue 1 en
dc.citation.jtitle FEMS Immunology and Medical Microbiology en
dc.citation.volume 63 en
dc.citation.pages 1-9 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/21668514
dc.citation.jabbreviation FEMS Immunol Med Microbiol en


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record