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Vernal keratoconjunctivitis in school children in Rwanda and its association with socio-economic status: a population-based survey

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dc.contributor.author De Smedt, S.
dc.contributor.author Nkurikiye, J.
dc.contributor.author Fonteyne, Y.
dc.contributor.author Hogewoning, A.
dc.contributor.author Van Esbroeck, M.
dc.contributor.author Bacquer, D. D.
dc.contributor.author Tuft, S.
dc.contributor.author Gilbert, C.
dc.contributor.author Delanghe, J.
dc.contributor.author Kestelyn, P.
dc.date.accessioned 2011-10-27T07:38:58Z
dc.date.available 2011-10-27T07:38:58Z
dc.date.issued 2011
dc.identifier.issn 0002-9637
dc.identifier.doi http://dx.doi.org/10.4269/ajtmh.2011.11-0291
dc.identifier.other ITG-C5A
dc.identifier.other CLINIC
dc.identifier.other U-CLIBIO
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other Abstract
dc.identifier.other UPD39
dc.identifier.uri http://hdl.handle.net/10390/6707
dc.description.abstract Vernal keratoconjunctivitis (VKC) is an allergic eye disease and an important cause of hospital referral among children in Africa and Asia. Hospital-based studies have suggested a role for parasites in its pathogenesis. To determine the prevalence and risk factors for VKC in Central Africa, we conducted a nested population-based case control study in Rwanda, involving randomly selected primary schools from different environments (rural/urban) and climate. A prevalence of VKC of 4.0% (95% confidence interval 3.3-4.7%) was found among 3,041 children studied (participation rate 94.7%). The intestinal parasitic burden was not related to VKC. Besides hot dry climate (odds ratio [OR] = 1.5, P = 0.05) and male gender (OR = 1.7, P = 0.005), multivariate analysis identified higher economic status as a risk for VKC (OR = 1.4, P = 0.005). The effect on VKC of higher economic status appears not to act through differences in parasitic intestinal load. en
dc.language English en
dc.subject Parasitic diseases en
dc.subject Eye diseases en
dc.subject Vernal en
dc.subject Keratoconjunctivitis en
dc.subject Prevalence en
dc.subject Schoolchildren en
dc.subject Risk factors en
dc.subject Associations en
dc.subject Socioeconomic status en
dc.subject Gender en
dc.subject Race en
dc.subject Genetic predisposition to disease en
dc.subject Climate en
dc.subject Antibodies en
dc.subject Strongyloides en
dc.subject Asthma en
dc.subject Rwanda en
dc.subject Africa, Central en
dc.title Vernal keratoconjunctivitis in school children in Rwanda and its association with socio-economic status: a population-based survey en
dc.type Article en
dc.citation.issue 4 en
dc.citation.jtitle American Journal of Tropical Medicine and Hygiene en
dc.citation.volume 85 en
dc.citation.pages 711-717 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/21976577
dc.citation.jabbreviation Am J Trop Med Hyg en


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