Institute of Tropical Medicine Antwerp
Foundation of Public Utility

Association of haptoglobin phenotypes with the development of Kaposi's sarcoma in HIV patients

DSpace/Manakin Repository

Show simple item record

dc.contributor.author Speeckaert, R.
dc.contributor.author Colebunders, R.
dc.contributor.author Boelaert, J. R.
dc.contributor.author Brochez, L.
dc.contributor.author Van Acker, J.
dc.contributor.author Van Wanzeele, F.
dc.contributor.author Hemmer, R.
dc.contributor.author Speeckaert, M. M.
dc.contributor.author Verhofstede, C.
dc.contributor.author De Buyzere, M.
dc.contributor.author Arendt, V.
dc.contributor.author Plum, J.
dc.contributor.author Delanghe, J. R.
dc.date.accessioned 2011-11-30T09:51:53Z
dc.date.available 2011-11-30T09:51:53Z
dc.date.issued 2011
dc.identifier.issn 0340-3696
dc.identifier.doi http://dx.doi.org/10.1007/s00403-011-1161-9
dc.identifier.other ITG-C2A
dc.identifier.other CLINIC
dc.identifier.other U-HIVCLI
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other Abstract
dc.identifier.other UPD40
dc.identifier.uri http://hdl.handle.net/10390/6750
dc.description.abstract Kaposi's sarcoma (KS) is a rare cutaneous tumor caused by human herpes virus-8 (HHV-8) infection that preferentially develops in case of severe immunosuppression, such as in HIV/AIDS disease. Haptoglobin (Hp), a polymorphic multifunctional plasma protein, exerts several immunomodulatory effects and is characterized by a genetic polymorphism leading to three major phenotypes (Hp 1-1, Hp 2-1 and Hp 2-2). This study investigated the influence of Hp genetic polymorphism on the development of KS in HIV-positive patients. 661 HIV patients were enrolled in the study with a median age of 35 years and a median follow-up time of 57 months. Hp phenotyping was performed using hemoglobin-supplemented starch gel electrophoresis. In case of low Hp concentration high pressure gel permeation chromatography (HPGPC) was used. The Hp 1-1 phenotype was associated with a significant higher risk of KS compared to the combined group of Hp 2-1 and Hp 2-2 patients (p < 0.0005) which remained significant after adjustment for possible confounding variables (age, gender and AIDS status) (p < 0.001). In contrast, the Hp 2-1 phenotype carried the lowest risk. These findings point to the involvement of Hp phenotypes in the pathogenesis of KS, which may be due to a difference in skin immunosurveillance between the Hp phenotypes. en
dc.language English en
dc.subject Viral diseases en
dc.subject HIV en
dc.subject AIDS en
dc.subject Kaposi sarcoma en
dc.subject Herpes virus type 8 en
dc.subject Disease progression en
dc.subject Immunosuppression en
dc.subject Risk factors en
dc.subject Associations en
dc.subject Haptoglobin en
dc.subject Plasma proteins en
dc.subject Polymorphism en
dc.subject Phenotyping en
dc.subject Belgium en
dc.subject Luxembourg en
dc.subject Europe, West en
dc.title Association of haptoglobin phenotypes with the development of Kaposi's sarcoma in HIV patients en
dc.type Article en
dc.citation.issue 10 en
dc.citation.jtitle Archives of Dermatological Research en
dc.citation.volume 303 en
dc.citation.pages 763-769 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/21748360
dc.citation.jabbreviation Arch Dermatol Res en


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record