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Prevalence and correlates of Mycoplasma genitalium infection among female sex workers in Kampala, Uganda

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dc.contributor.author Vandepitte, J.
dc.contributor.author Muller, E.
dc.contributor.author Bukenya, J.
dc.contributor.author Nakubulwa, S.
dc.contributor.author Kyakuwa, N.
dc.contributor.author Buvé, A.
dc.contributor.author Weiss, H.
dc.contributor.author Hayes, R.
dc.contributor.author Grosskurth, H.
dc.date.accessioned 2012-01-17T16:17:20Z
dc.date.available 2012-01-17T16:17:20Z
dc.date.issued 2011
dc.identifier.issn 0022-1899
dc.identifier.doi http://dx.doi.org/10.1093/infdis/jir733
dc.identifier.other ITG-M6A
dc.identifier.other MICRO
dc.identifier.other U-HIVSTD
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other Abstract
dc.identifier.other UPD42
dc.identifier.other FTA
dc.identifier.uri http://hdl.handle.net/10390/6790
dc.description.abstract Background. The importance of Mycoplasma genitalium in human immunodeficiency virus (HIV)-burdened sub-Saharan Africa is relatively unknown. We assessed the prevalence and explored determinants of this emerging sexually transmitted infection (STI) in high-risk women in Uganda.Methods. Endocervical swabs from 1025 female sex workers in Kampala were tested for Mycoplasma genitalium using a commercial Real-TM polymerase chain reaction assay. Factors associated with prevalent Mycoplasma genitalium, including sociodemographics, reproductive history, risk behavior, and HIV and other STIs, were examined using multivariable logistic regression.Results. The prevalence of Mycoplasma genitalium was 14% and higher in HIV-positive women than in HIV-negative women (adjusted odds ratio [OR], 1.64; 95% confidence interval [CI], 1.12-2.41). Mycoplasma genitalium infection was less prevalent in older women (adjusted OR, 0.61; 95% CI, .41-.90 for women ages 25-34 years vs <25 years; adjusted OR, 0.32; 95% CI, .15-.71 for women >/=35 years vs those <25 years) and in those who had been pregnant but never had a live birth (adjusted OR, 2.25; 95% CI, 1.04-4.88). Mycoplasma genitalium was associated with Neisseria gonorrhoeae (adjusted OR, 1.84; 95% CI, 1.13-2.98) and with Candida infection (adjusted OR, 0.41; 95% CI, .18-.91), and there was some evidence of association with Trichomonas vaginalis (adjusted OR, 1.56; 95% CI, 1.00-2.44).Conclusions. The relatively high prevalence of Mycoplasma genitalium and its association with prevalent HIV urgently calls for further research to explore the potential role this emerging STI plays in the acquisition and transmission of HIV infection. en
dc.language English en
dc.subject Sexually transmitted diseases en
dc.subject STD en
dc.subject Mycoplasma genitalium en
dc.subject Prevalence en
dc.subject Women en
dc.subject Prostitutes en
dc.subject Determinants en
dc.subject Risk factors en
dc.subject Sociodemographic aspects en
dc.subject Reproductive health en
dc.subject Pregnancy en
dc.subject Risk behavior en
dc.subject Co-infections en
dc.subject Viral diseases en
dc.subject HIV en
dc.subject AIDS en
dc.subject Age en
dc.subject Associations en
dc.subject Neisseria gonorrhoeae en
dc.subject Candida en
dc.subject Trichomonas vaginalis en
dc.subject Uganda en
dc.subject Africa, East en
dc.title Prevalence and correlates of Mycoplasma genitalium infection among female sex workers in Kampala, Uganda en
dc.type Article en
dc.citation.issue 2 en
dc.citation.jtitle Journal of Infectious Diseases en
dc.citation.volume 205 en
dc.citation.pages 289-296 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/22102734
dc.citation.jabbreviation J Infect Dis en


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