Institute of Tropical Medicine Antwerp
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Surface-engineered polyelectrolyte multilayer capsules-synthetic vaccines mimicking microbial structure and function

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dc.contributor.author De Geest, B. G.
dc.contributor.author Willart, M. A.
dc.contributor.author Lambrecht, B. N.
dc.contributor.author Pollard, C.
dc.contributor.author Vervaet, C.
dc.contributor.author Remon, J. P.
dc.contributor.author Grooten, J.
dc.contributor.author De Koker, S.
dc.date.accessioned 2012-04-25T14:01:35Z
dc.date.available 2012-04-25T14:01:35Z
dc.date.issued 2012
dc.identifier.issn 1433-7851
dc.identifier.doi http://dx.doi.org/10.1002/anie.201200048
dc.identifier.other ITG-B4B
dc.identifier.other DBM
dc.identifier.other U-VIROL
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other Abstract
dc.identifier.other UPD45
dc.identifier.uri http://hdl.handle.net/10390/6954
dc.description.abstract Immunizing: To evoke highly potent immune responses against recombinant antigens, hollow capsules consisting of layers of dextran sulphate and poly-L-arginine that encapsulate the antigen ovalbumin (orange circles) were coated with immune-activating CpG-containing oligonucleotides (green). These capsules were readily internalized by dendritic cells and showed activity in further immunization experiments. en
dc.language English en
dc.subject Viral diseases en
dc.subject HIV en
dc.subject AIDS en
dc.subject Vaccine development en
dc.subject Cellular en
dc.subject Immune response en
dc.subject T cells en
dc.subject CD4-positive-T-lymphocytes en
dc.subject CD8-positive-T-lymphocytes en
dc.subject Antigens en
dc.subject Mimicking en
dc.subject Polyelectrolyte multilayer capsules en
dc.subject Global en
dc.title Surface-engineered polyelectrolyte multilayer capsules-synthetic vaccines mimicking microbial structure and function en
dc.type Article en
dc.citation.issue 13 en
dc.citation.jtitle Angewandte Chemie (International Edition in English) en
dc.citation.volume 51 en
dc.citation.pages 3862-3866 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/22411781
dc.citation.jabbreviation Angew Chem Int Ed Engl en


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