| dc.contributor.author |
De Geest, B. G. |
|
| dc.contributor.author |
Willart, M. A. |
|
| dc.contributor.author |
Lambrecht, B. N. |
|
| dc.contributor.author |
Pollard, C. |
|
| dc.contributor.author |
Vervaet, C. |
|
| dc.contributor.author |
Remon, J. P. |
|
| dc.contributor.author |
Grooten, J. |
|
| dc.contributor.author |
De Koker, S. |
|
| dc.date.accessioned |
2012-04-25T14:01:35Z |
|
| dc.date.available |
2012-04-25T14:01:35Z |
|
| dc.date.issued |
2012 |
|
| dc.identifier.issn |
1433-7851 |
|
| dc.identifier.doi |
http://dx.doi.org/10.1002/anie.201200048 |
|
| dc.identifier.other |
ITG-B4B |
|
| dc.identifier.other |
DBM |
|
| dc.identifier.other |
U-VIROL |
|
| dc.identifier.other |
JIF |
|
| dc.identifier.other |
DOI |
|
| dc.identifier.other |
Abstract |
|
| dc.identifier.other |
UPD45 |
|
| dc.identifier.uri |
http://hdl.handle.net/10390/6954 |
|
| dc.description.abstract |
Immunizing: To evoke highly potent immune responses against recombinant antigens, hollow capsules consisting of layers of dextran sulphate and poly-L-arginine that encapsulate the antigen ovalbumin (orange circles) were coated with immune-activating CpG-containing oligonucleotides (green). These capsules were readily internalized by dendritic cells and showed activity in further immunization experiments. |
en |
| dc.language |
English |
en |
| dc.subject |
Viral diseases |
en |
| dc.subject |
HIV |
en |
| dc.subject |
AIDS |
en |
| dc.subject |
Vaccine development |
en |
| dc.subject |
Cellular |
en |
| dc.subject |
Immune response |
en |
| dc.subject |
T cells |
en |
| dc.subject |
CD4-positive-T-lymphocytes |
en |
| dc.subject |
CD8-positive-T-lymphocytes |
en |
| dc.subject |
Antigens |
en |
| dc.subject |
Mimicking |
en |
| dc.subject |
Polyelectrolyte multilayer capsules |
en |
| dc.subject |
Global |
en |
| dc.title |
Surface-engineered polyelectrolyte multilayer capsules-synthetic vaccines mimicking microbial structure and function |
en |
| dc.type |
Article |
en |
| dc.citation.issue |
13 |
en |
| dc.citation.jtitle |
Angewandte Chemie (International Edition in English) |
en |
| dc.citation.volume |
51 |
en |
| dc.citation.pages |
3862-3866 |
en |
| dc.identifier.pmid |
http://www.ncbi.nlm.nih.gov/pubmed/22411781 |
|
| dc.citation.jabbreviation |
Angew Chem Int Ed Engl |
en |