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Taenia solium infections in a rural area of eastern Zambia; a community based study

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dc.contributor.author Mwape, K. E.
dc.contributor.author Phiri, I. K.
dc.contributor.author Praet, N.
dc.contributor.author Muma, J. B.
dc.contributor.author Zulu, G.
dc.contributor.author Van den Bossche, P.
dc.contributor.author De Deken, R.
dc.contributor.author Speybroeck, N.
dc.contributor.author Dorny, P.
dc.contributor.author Gabriël, S.
dc.date.accessioned 2012-04-26T13:17:54Z
dc.date.available 2012-04-26T13:17:54Z
dc.date.issued 2012
dc.identifier.issn 1935-2727
dc.identifier.doi http://dx.doi.org/10.1371/journal.pntd.0001594
dc.identifier.other ITG-B3A
dc.identifier.other ITG-B6A
dc.identifier.other ITG-B7A
dc.identifier.other ITG-B9A
dc.identifier.other ITG-BLB
dc.identifier.other DBM
dc.identifier.other U-VHELM
dc.identifier.other U-VCONT
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other Abstract
dc.identifier.other UPD45
dc.identifier.other FTA
dc.identifier.uri http://hdl.handle.net/10390/6971
dc.description.abstract BACKGROUND: Taenia solium taeniosis/cysticercosis is a parasitic infection occurring in many developing countries. Data on the status of human infections in Zambia is largely lacking. We conducted a community-based study in Eastern Zambia to determine the prevalence of human taeniosis and cysticercosis in a rural community. METHODS AND FINDINGS: Stool and serum samples were collected from willing participants. Geographical references of the participants' households were determined and household questionnaires administered. Taeniosis was diagnosed in stool samples by coprology and by the polyclonal antibody-based copro-antigen enzyme-linked immunosorbent assay (copro-Ag ELISA), while cysticercosis was diagnosed in serum by the B158/B60 monoclonal antibody-based antigen ELISA (sero-Ag ELISA). Identification of the collected tapeworm after niclosamide treatment and purgation was done using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). A total of 255 households from 20 villages participated in the study, 718 stool and 708 serum samples were collected and examined. Forty-five faecal samples (6.3%) were found positive for taeniosis on copro-Ag ELISA while circulating cysticercus antigen was detected in 5.8% (41/708) individuals. The tapeworm recovered from one of the cases was confirmed to be T. solium on PCR-RFLP. Seropositivity (cysticercosis) was significantly positively related to age (p = 0.00) and to copro-Ag positivity (taeniosis) (p = 0.03) but not to gender. Change point analysis revealed that the frequency of cysticercus antigens increased significantly in individuals above the age of 30. Copro-Ag positivity was not related to age or gender. The following risk factors were noted to be present in the study community: free-range pig husbandry system and poor sanitation with 47.8% of the households visited lacking latrines. CONCLUSIONS: This study has recorded high taeniosis and cysticercosis prevalences and identified the need for further studies on transmission dynamics and impact of the disease on the local people. en
dc.language English en
dc.subject Animal diseases en
dc.subject Helminthic diseases en
dc.subject Cysticercosis en
dc.subject Taeniasis en
dc.subject Taenia solium en
dc.subject Prevalence en
dc.subject Diagnosis en
dc.subject ELISA en
dc.subject PCR-RFLP en
dc.subject Geographical distribution en
dc.subject Treatment en
dc.subject Niclosamide en
dc.subject Risk factors en
dc.subject Age distribution en
dc.subject Animal husbandry en
dc.subject Pig farms en
dc.subject Sanitation en
dc.subject Zambia en
dc.subject Africa, Southern en
dc.title Taenia solium infections in a rural area of eastern Zambia; a community based study en
dc.type Article-E en
dc.citation.issue 3 en
dc.citation.jtitle PLoS Neglected Tropical Diseases en
dc.citation.volume 6 en
dc.citation.pages e1594 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/22479664
dc.citation.jabbreviation PLoS Negl Trop Dis en


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