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Field detection of resistance to isometamidium chloride and diminazene aceturate in Trypanosoma vivax from the region of the Boucle du Mouhoun in Burkina Faso

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dc.contributor.author Sow, A.
dc.contributor.author Sidibé, I.
dc.contributor.author Bengaly, Z.
dc.contributor.author Marcotty, T.
dc.contributor.author Séré, M.
dc.contributor.author Diallo, A.
dc.contributor.author Vitouley, H. S.
dc.contributor.author Nebié, R. L.
dc.contributor.author Ouédraogo, M.
dc.contributor.author Akoda, G. K.
dc.contributor.author Van den Bossche, P.
dc.contributor.author Van Den Abbeele, J.
dc.contributor.author De Deken, R.
dc.contributor.author Delespaux, V.
dc.date.accessioned 2012-05-25T09:29:14Z
dc.date.available 2012-05-25T09:29:14Z
dc.date.issued 2012
dc.identifier.issn 0304-4017
dc.identifier.doi http://dx.doi.org/10.1016/j.vetpar.2011.12.019
dc.identifier.other ITG-B4A
dc.identifier.other ITG-B11A
dc.identifier.other ITG-B12A
dc.identifier.other ITG-B13A
dc.identifier.other ITG-BLA
dc.identifier.other U-VHELM
dc.identifier.other U-VCONT
dc.identifier.other U-VPROT
dc.identifier.other U-VEPID
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other Abstract
dc.identifier.other UPD48
dc.identifier.uri http://hdl.handle.net/10390/7047
dc.description.abstract A longitudinal study assessed the chemoresistance to isometamidium chloride (ISM) and diminazene aceturate (DA) in the region of the Boucle du Mouhoun in Burkina Faso. A preliminary cross-sectional survey allowed the identification of the 10 villages with the highest parasitological prevalences (from 2.1% to 16.1%). In each of these 10 villages, two herds of approximately 50 bovines were selected, one being treated with ISM (1mg/kg b.w.) and the other remaining untreated as control group. All animals (treated and untreated herds) becoming infected were treated with DA (3.5mg/kg b.w.). In total, 978 head of cattle were followed up. Fortnightly controls of the parasitaemia and PCV were carried out during 8 weeks. The main trypanosome species was Trypanosoma vivax (83.6%) followed by Trypanosoma congolense (16.4%). In two villages, less than 25% of the control untreated cattle became positive indicating no need to use prophylactic treatment. These two villages were not further studied. Resistance to ISM was observed in 5 of the remaining 8 villages (Debe, Bendougou, Kangotenga, Mou and Laro) where the relative risk (control/treated hazard ratios) of becoming infected was lower than 2 i.e. between 0.89 (95% CI: 0.43-2.74) and 1.75 (95% CI: 0.57-5.37). In contrast, this study did not show evidence of resistance to DA in the surveyed villages with only 8.6% (n=93) of the cattle relapsing after treatment. Our results suggest that because of the low prevalence of multiple resistances in the area a meticulous use of the sanative pair system would constitute the best option to delay as much as possible the spread of chemoresistance till complete eradication of the disease by vector control operations. en
dc.language English en
dc.subject Protozoal diseases en
dc.subject Animal diseases en
dc.subject Bovine en
dc.subject Trypanosomiasis en
dc.subject Trypanosoma vivax en
dc.subject Trypanosoma congolense en
dc.subject Vectors en
dc.subject Tsetse flies en
dc.subject Glossina en
dc.subject Drug resistance en
dc.subject Field research en
dc.subject Detection en
dc.subject Isometamidium chloride en
dc.subject Diminazene aceturate en
dc.subject Burkina Faso en
dc.subject Africa, West en
dc.title Field detection of resistance to isometamidium chloride and diminazene aceturate in Trypanosoma vivax from the region of the Boucle du Mouhoun in Burkina Faso en
dc.type Article en
dc.citation.issue 1-2 en
dc.citation.jtitle Veterinary Parasitology en
dc.citation.volume 187 en
dc.citation.pages 105-111 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/22264748
dc.citation.jabbreviation Vet Parasitol en


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