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Relatively low primary drug resistant tuberculosis in southwestern Ethiopia

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dc.contributor.author Abebe, G.
dc.contributor.author Abdissa, K.
dc.contributor.author Abdissa, A.
dc.contributor.author Apers, L.
dc.contributor.author Agonafir, M.
dc.contributor.author de Jong, B. C.
dc.contributor.author Colebunders, R.
dc.date.accessioned 2012-05-25T10:49:47Z
dc.date.available 2012-05-25T10:49:47Z
dc.date.issued 2012
dc.identifier.issn 1756-0500
dc.identifier.doi http://dx.doi.org/10.1186/1756-0500-5-225
dc.identifier.other ITG-C4A
dc.identifier.other ITG-B6A
dc.identifier.other ITG-CLA
dc.identifier.other MULTI
dc.identifier.other DCS
dc.identifier.other U-STDCLI
dc.identifier.other U-MYCOB
dc.identifier.other U-HIVCLI
dc.identifier.other DOI
dc.identifier.other CPDF
dc.identifier.other Abstract
dc.identifier.other UPD48
dc.identifier.uri http://hdl.handle.net/10390/7049
dc.description.abstract BACKGROUND: The prevalence of drug resistant tuberculosis (TB) in Ethiopia in general, and Jimma area in particular, is not well documented. We conducted a study at Jimma University specialized hospital in southwest Ethiopia among new cases of smear positive TB patients to determine the pattern of resistance to first-line drugs. METHODS: A health institution based cross sectional study was conducted from November 2010 to September 2011. Any newly diagnosed smear positive TB patient 18 years and above was included in the study. Demographic and related data were collected by trained personnel using a pretested structured questionnaire. Mycobacterial drug susceptibility testing (DST) to the first line drugs isoniazid (INH), rifampicin (RIF), ethambutol (EMB) and streptomycin (STM)] was performed on cultures using the indirect proportion method. M. tuberculosis complex (MTBC) was identified with the Capilia TB-Neo test. RESULTS: 136 patients were enrolled in the study. Resistance to at least one drug was identified in 18.4%. The highest prevalence of resistance to any drug was identified against INH (13.2%) followed by STM (8.1%). There was no statistically significant difference in the proportion of any resistance by sex, age, HIV status and history of being imprisoned. The highest mono resistance was observed against INH (7.4%). Mono resistance to streptomycin was associated with HIV infection (crude OR 15.63, 95%CI: 1.31, 187). Multidrug-resistance TB (MDR-TB) was observed in two patients (1.5%). CONCLUSION: Resistance to at least one drug was 18.4% (INH-13.2% and STM-8.1%). STM resistance was associated with HIV positivity. There was relatively low prevalence of MDR-TB yet INH resistance was common around Jimma. The capacity of laboratories for TB culture and DST should be strengthened, in order to correctly manage TB patients and avoid amplification of drug resistance. en
dc.language English en
dc.subject Bacterial diseases en
dc.subject Tuberculosis en
dc.subject Mycobacterium tuberculosis complex en
dc.subject Associations en
dc.subject Viral diseases en
dc.subject HIV en
dc.subject AIDS en
dc.subject Prevalence en
dc.subject Hospitalization en
dc.subject Smear-positive en
dc.subject Drug resistance en
dc.subject First-line drugs en
dc.subject Isoniazid en
dc.subject Rifampicin en
dc.subject Ethambutol en
dc.subject Streptomycin en
dc.subject Risk factors en
dc.subject Ethiopia en
dc.subject Africa, East en
dc.title Relatively low primary drug resistant tuberculosis in southwestern Ethiopia en
dc.type Article-E en
dc.citation.issue 225 en
dc.citation.jtitle BMC Research Notes en
dc.citation.volume 5 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/22574696
dc.citation.jabbreviation BMC Res Notes en


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