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Susceptibility of Grammomys surdaster thicket rats to Trypanosoma brucei gambiense infection

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dc.contributor.author Büscher, P. en_US
dc.contributor.author Kahremere Bin Shamamba, S. en_US
dc.contributor.author Mumba Ngoyi, D. en_US
dc.contributor.author Pyana, P. en_US
dc.contributor.author Baelmans, R. en_US
dc.contributor.author Magnus, E. en_US
dc.contributor.author Van Overmeir, C. en_US
dc.contributor.author Büscher, P. en_US
dc.date.accessioned 2007-12-06T14:33:10Z
dc.date.available 2007-12-06T14:33:10Z
dc.date.issued 2005 en_US
dc.identifier.issn 1360-2276 en_US
dc.identifier.doi http://dx.doi.org/10.1111/j.1365-3156.2005.01468.x
dc.identifier.other ITG-P1A en_US
dc.identifier.other ITG-I5B en_US
dc.identifier.other ITG-I6B en_US
dc.identifier.other ITG-PLB en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-SEROL en_US
dc.identifier.other U-MALAR en_US
dc.identifier.other INTER en_US
dc.identifier.other U-TTP en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other FTB en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/71
dc.description The definitive version is available at www3.interscience.wiley.com
dc.description.abstract Human African Trypanosomiasis is caused by Trypanosoma brucei gambiense and T. b. rhodesiense. Historically, a treatment relapse rate of about 5% is observed in patients treated with melarsoprol, an arsenical derivative used for treatment of both gambiense and rhodesiense second stage sleeping sickness. More recently, relapse rates up to 30% are noted in gambiense sleeping sickness foci in Angola, Sudan and Uganda. Therefore, WHO established a Network on Treatment Failure and Drug Resistance in Sleeping Sickness. One of its objectives is to improve isolation of T. b. gambiense from relapsing cases for research on drug resistance mechanisms. Trypanosoma b. gambiense isolation techniques suffer from low success rates and long periods needed to adapt the parasite to its new host. Usually, rodents are inoculated with patient's blood or cerebrospinal fluid and sub-passaged until the strain becomes sufficiently adapted to yield high parasitaemia within few days after inoculation. Until now, the best recipient for T. b. gambiense is Mastomys natalensis, with a success rate of about 50%. In this study, Grammomys surdaster (former Thamnomys surdaster) was investigated as a potential recipient for isolation of T. b. gambiense. Comparative experimental infections of Swiss mice, Wistar rats and G. surdaster thicket rats with T. b. gambiense clearly show that this trypanosome grows faster in G. surdaster. Inoculation of the same rodent species with patient's blood and cerebrospinal fluid in Kinshasa (R.D. Congo) confirms the observation that the thicket rats are more susceptible to T. b. gambiense infection than typical laboratory rodents.
dc.language English en_US
dc.publisher Blackwell Publishing
dc.subject Protozoal diseases en_US
dc.subject Trypanosomiasis, African en_US
dc.subject Trypanosoma brucei gambiense en_US
dc.subject Drug resistance en_US
dc.subject Melarsoprol en_US
dc.subject Recurrence en_US
dc.subject Laboratory animals en_US
dc.subject Rodents en_US
dc.subject Grammomys surdaster en_US
dc.subject Disease susceptibility en_US
dc.subject Isolation en_US
dc.subject Congo-Kinshasa en_US
dc.subject Africa, Central en_US
dc.title Susceptibility of Grammomys surdaster thicket rats to Trypanosoma brucei gambiense infection en_US
dc.type Article en_US
dc.citation.issue 9 en_US
dc.citation.jtitle Tropical Medicine and International Health en_US
dc.citation.volume 10 en_US
dc.citation.pages 850-855 en_US
dc.publisher.place Oxford
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/16135191
dc.citation.jabbreviation Trop Med Int Health en_US


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