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Shifting from wild to domestic hosts: the effect on the transmission of Trypanosoma congolense to tsetse flies

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dc.contributor.author Chitanga, S.
dc.contributor.author Namangala, B.
dc.contributor.author De Deken, R.
dc.contributor.author Marcotty, T.
dc.date.accessioned 2013-02-08T16:17:39Z
dc.date.available 2013-02-08T16:17:39Z
dc.date.issued 2013
dc.identifier.issn 0001-706X
dc.identifier.doi http://dx.doi.org/10.1016/j.actatropica.2012.08.019
dc.identifier.other ITG-B3A
dc.identifier.other ITG-BLA
dc.identifier.other DBM
dc.identifier.other U-VEPID
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other Abstract
dc.identifier.other UPD54
dc.identifier.uri http://hdl.handle.net/10390/7304
dc.description.abstract The epidemiology and impact of animal African trypanosomosis is influenced by the transmissibility and the pathogenicity of the circulating trypanosome strains in a particular biotope. The transmissibility of 22T. congolense strains isolated from domestic and wild animals was evaluated in a total of 1213 flies. Multivariate mixed models were used to compare infection and maturation rates in function of trypanosome origin (domestic or sylvatic) and pathogenicity. Both trypanosome pathogenicity and origin significantly affected the ability to establish a midgut infection in tsetse flies but not the maturation rates. The interaction between pathogenicity and origin was not significant. Since being pathogenic and having a domestic origin both increased transmissibility, dominant lowly pathogenic trypanosomes from domestic environments and highly pathogenic trypanosomes from sylvatic environments presented similar levels of transmissibility: 12% and 15%, respectively. Blood meals with parasite concentration ranging from 0,05 to 50 trypanosomes/mul blood for 3 strains of T. congolense were provided to different batches of tsetse flies to evaluate the relationship between the parasite load in blood meals and the likelihood for a fly to become infected. A linear relationship between parasite load and transmissibility was observed at low parasitaemia and a plateau was observed for meals containing more than 5 trypanosomes/mul. Maximum transmission was reached with 12,5 trypanosomes/mul blood. About 50% of the flies were refractory to T. congolense, whatever their concentration in the blood meal. The results suggest that the dose - transmissibility relationship presents a similar profile for different T. congolense isolates. en
dc.language English en
dc.subject Animal diseases en
dc.subject Nagana en
dc.subject Trypanosoma congolense en
dc.subject Vectors en
dc.subject Tsetse flies en
dc.subject Glossina morsitans en
dc.subject Epidemiology en
dc.subject Impact en
dc.subject Evaluation en
dc.subject Transmissibility en
dc.subject Strains en
dc.subject Domestic animals en
dc.subject Cattle en
dc.subject Livestock en
dc.subject Wildlife en
dc.subject Wild animals en
dc.subject Infection rates en
dc.subject Maturation en
dc.subject Pathogenicity en
dc.subject Origin en
dc.subject Bloodmeal en
dc.subject Concentration en
dc.subject Parasite density en
dc.subject Infectivity en
dc.subject Refractoriness en
dc.title Shifting from wild to domestic hosts: the effect on the transmission of Trypanosoma congolense to tsetse flies en
dc.type Article en
dc.citation.issue 1 en
dc.citation.jtitle Acta Tropica en
dc.citation.volume 125 en
dc.citation.pages 32-36 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/23000543
dc.citation.jabbreviation Acta Trop en


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