Institute of Tropical Medicine Antwerp
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Th17 cells are associated with pathology in human schistosomiasis

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dc.contributor.author Mbow, M.
dc.contributor.author Larkin, B. M.
dc.contributor.author Meurs, L.
dc.contributor.author Wammes, L. J.
dc.contributor.author de Jong, S. E.
dc.contributor.author Labuda, L. A.
dc.contributor.author Camara, M.
dc.contributor.author Smits, H. H.
dc.contributor.author Polman, K.
dc.contributor.author Dieye, T. N.
dc.contributor.author Mboup, S.
dc.contributor.author Stadecker, M. J.
dc.contributor.author Yazdanbakhsh, M.
dc.date.accessioned 2013-02-13T14:10:19Z
dc.date.available 2013-02-13T14:10:19Z
dc.date.issued 2013
dc.identifier.issn 0022-1899
dc.identifier.doi http://dx.doi.org/10.1093/infdis/jis654
dc.identifier.other ITG-B1B
dc.identifier.other ITG-B3B
dc.identifier.other ITG-B9A
dc.identifier.other DBM
dc.identifier.other U-MHELM
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other Abstract
dc.identifier.other UPD54
dc.identifier.uri http://hdl.handle.net/10390/7321
dc.description.abstract Background. Schistosome infections are often clinically silent, but some individuals develop severe pathological reactions. In several disease processes Th17 cells have been linked to tissue injuries, while regulatory T (Treg) cells are thought to down-modulate inflammatory reactions. We assessed whether bladder pathology in human Schistosoma haematobium infection is related to the balance of Th17 and Treg cells. Using a murine model of Schistosoma mansoni infection we further investigated whether the peripheral profiles reflected ongoing events in tissues. Methods. We characterized T helper subsets in the peripheral blood of children residing in a S. haematobium-endemic area and in peripheral blood as well as in spleen and hepatic granulomas of S. mansoni-infected high-pathology CBA and low-pathology C57BL/6 mice. S. haematobium-infected children with bladder pathology had a significantly higher percentage of Th17 cells than those without pathology. Moreover, the Th17/Treg ratios were significantly higher in children with pathology compared to infected children without pathology. Results. Percentages of IL-17-producing cells were significantly more abundant in the spleen and granulomas of CBA compared to C57BL/6 mice. This difference was also reflected in the peripheral blood. Conclusions. Our results indicate for the first time that Th17 cells may be involved in the pathogenesis of human schistosomiasis. en
dc.language English en
dc.subject Helminthic diseases en
dc.subject Schistosomiasis en
dc.subject Schistosoma haematobium en
dc.subject Schistosoma mansoni en
dc.subject Snails en
dc.subject Pathology en
dc.subject Pathogenesis en
dc.subject T helper cells en
dc.subject Th17 cells en
dc.subject Bladder en
dc.subject Characterization en
dc.subject Children en
dc.subject Mice en
dc.subject Interleukin-17 en
dc.subject Spleen en
dc.subject Peripheral blood en
dc.subject Granuloma en
dc.subject Senegal en
dc.subject Africa, East en
dc.title Th17 cells are associated with pathology in human schistosomiasis en
dc.type Article en
dc.citation.issue 1 en
dc.citation.jtitle Journal of Infectious Diseases en
dc.citation.volume 207 en
dc.citation.pages 186-195 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/23087431
dc.citation.jabbreviation J Infect Dis en


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