Institute of Tropical Medicine Antwerp
Foundation of Public Utility

Generic sodium stibogluconate is as safe and effective as branded meglumine antimoniate, for the treatment of tegumentary leishmaniasis in Isiboro Secure Park, Bolivia

DSpace/Manakin Repository

Show simple item record

dc.contributor.author Bermùdez, H. en_US
dc.contributor.author Rojas, E. en_US
dc.contributor.author Garcia, L. en_US
dc.contributor.author Desjeux, P. en_US
dc.contributor.author Dujardin, J. C. en_US
dc.contributor.author Boelaert, M. en_US
dc.contributor.author Chappuis, F. en_US
dc.date.accessioned 2007-12-06T14:33:10Z
dc.date.available 2007-12-06T14:33:10Z
dc.date.issued 2006 en_US
dc.identifier.issn 0272-4936 en_US
dc.identifier.doi http://dx.doi.org/10.1179/136485906X118495
dc.identifier.other ITG-P5A en_US
dc.identifier.other ITG-H6A en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-PROTO en_US
dc.identifier.other HEALTH en_US
dc.identifier.other U-EPID en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other MULTI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/73
dc.description.abstract Human cutaneous leishmaniasis (CL) and mucous leishmaniasis (ML) are highly endemic in Isiboro Secure Park, which lies in the Bolivian department of Cochabamba--an area where branded meglumine antimoniate (Glucantime) is expensive and poorly distributed. The safety and efficacy of generic sodium stibogluconate (SSG), from Albert David Ltd, was therefore explored, in CL and ML cases from the park, who were treated with 20 mg/kg.day for 20 and 30 days, respectively. A questionnaire recording adverse effects was completed by a physician in each treatment centre. Efficacy of treatment was assessed at the end of treatment and at follow-ups 1 month and 3, 6 and 12 months later. Overall, 146 patients completed treatment with SSG in 2003-2004. No fatalities or severe adverse effects were reported but mild to moderate adverse effects were noted in 41 (28%) of the patients. The incidence of adverse effects was significantly higher among the cases of ML than among the cases of CL. Of the 86 patients with CL who completed 6 months of follow-up, 81 (94.2%) were considered to have been clinically cured; a comparable cohort of 69 CL cases who had been treated with Glucantime in 2001-2002 showed a similar frequency of clinical cure (90%). Generic SSG was shown to be safe and efficacious for the treatment of tegumentary leishmaniasis in Bolivia. Being several times cheaper than Glucantime, it could contribute to improving the access of CL and ML patients to treatment, not only in Bolivia but also in other countries of Latin America. en_US
dc.language English en_US
dc.subject Protozoal diseases en_US
dc.subject Leishmaniasis en_US
dc.subject Tegumentary en_US
dc.subject Drug therapy en_US
dc.subject Sodium stibogluconate en_US
dc.subject Generics en_US
dc.subject Safety en_US
dc.subject Adverse effects en_US
dc.subject Effectiveness en_US
dc.subject Bolivia en_US
dc.subject America, Latin en_US
dc.title Generic sodium stibogluconate is as safe and effective as branded meglumine antimoniate, for the treatment of tegumentary leishmaniasis in Isiboro Secure Park, Bolivia en_US
dc.type Article en_US
dc.citation.issue 7 en_US
dc.citation.jtitle Annals of Tropical Medicine and Parasitology en_US
dc.citation.volume 100 en_US
dc.citation.pages 591-600 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/16989685
dc.citation.jabbreviation Ann Trop Med Parasitol en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record