Institute of Tropical Medicine Antwerp
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Schistosome infection is associated with enhanced whole blood IL-10 secretion in response to cercarial excretory/secretory products

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Show simple item record Turner, J. D. en_US Meurs, L. en_US Dool, P. en_US Bourke, C. D. en_US Mbow, M. en_US Dieye, T. N. en_US Mboup, S. en_US Polman, K. en_US Mountford, A. P. en_US 2014-09-25T13:39:35Z 2014-09-25T13:39:35Z 2013 en_US
dc.identifier.issn 0141-9838 en_US
dc.identifier.doi en_US
dc.identifier.other ITG-B2B; ITG-B8A; DBM; U-MHELM; JIF; DOI; FTA; Abstract; UPD56 en_US
dc.description.abstract Infection of the human host by schistosome parasites follows exposure of skin to free-swimming cercariae and is aided by the release of excretory/secretory (E/S) material which is rich in proteases and glycoconjugates. This material provides the initial stimulus to cells of the innate immune system. The study presented here is the first to examine human innate/early immune responsiveness to cercarial E/S in subjects from an area co-endemic for Schistosoma mansoni and S. haematobium. We report that in infected participants stimulation of whole blood cultures with cercarial E/S material (termed 0-3hRP) caused the early (within 24 hours) release of greater quantities of regulatory IL-10, compared to un-infected controls. Elevated levels of IL-10 but not pro-inflammatory TNFalpha or IL-8 were most evident in participants co-infected with S. mansoni and S. haematobium and was accompanied by a higher 0-3hRP-specific IL-10: TNFalpha ratio. We also report that glycosylated components within 0-3hRP appear to be important factors in the stimulation of IL-8, TNFalpha and IL-10 production by whole blood cells. (c) 2013 Blackwell Publishing Ltd. en_US
dc.language English en_US
dc.subject Helminthic diseases en_US
dc.subject Schistosomiasis en_US
dc.subject Schistosoma mansoni en_US
dc.subject Schistosoma haematobium en_US
dc.subject Snails en_US
dc.subject Blood culture en_US
dc.subject Immune response en_US
dc.subject Cercariae en_US
dc.subject Antigens en_US
dc.subject IL-10 en_US
dc.subject Cytokines en_US
dc.subject Eosinophiles en_US
dc.subject Innate immunity en_US
dc.subject Infection intensity en_US
dc.subject Senegal en_US
dc.subject Africa, West en_US
dc.title Schistosome infection is associated with enhanced whole blood IL-10 secretion in response to cercarial excretory/secretory products en_US
dc.type Article en_US
dc.citation.issue 5-6 en_US
dc.citation.jtitle Parasite Immunology en_US
dc.citation.volume 35 en_US
dc.citation.pages 147-156 en_US
dc.identifier.pmid en_US
dc.citation.jabbreviation Parasite Immunol en_US

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