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Species distribution and antifungal susceptibility profile of Candida isolates from bloodstream infections in Lima, Peru

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dc.contributor.author Bustamante, B. en_US
dc.contributor.author Martins, M. A. en_US
dc.contributor.author Bonfietti, L. X. en_US
dc.contributor.author Szeszs, M. W. en_US
dc.contributor.author Jacobs, J. en_US
dc.contributor.author Garcia, C. en_US
dc.contributor.author Melhem, M. S. C. en_US
dc.date.accessioned 2014-09-25T13:39:43Z
dc.date.available 2014-09-25T13:39:43Z
dc.date.issued 2014 en_US
dc.identifier.issn 0022-2615 en_US
dc.identifier.doi http://dx.doi.org/10.1099/jmm.0.071167-0 en_US
dc.identifier.other ITG-C5A; DCS; U-TLM; JIF; DOI; FTA; Abstract; UPD56 en_US
dc.identifier.uri http://hdl.handle.net/10390/7829
dc.description.abstract Yeast identification and in vitro susceptibility testing provide helpful information for antifungal treatment. Few reports from Latin America region have been published. The aim of this study was identify the species of consecutive isolates from bloodstream infections diagnosed in nine hospitals in Lima, Peru, and determine their in vitro susceptibility to four antifungal drugs. We tested 153 isolates collected between October 2009 and August 2011.Isolates were identified by standard methods.PCR and PCR-RFLP assays were performed to discriminate C. albicans from C. dubliniensis and to identify the species of C. parapsilosis and C. glabrata complexes. Antifungal susceptibility testing for fluconazole, anidulafungin and voriconazole was performed according to M27-A3 method (CLSI) and for amphotericin B it was determined by Etest(R) method. The most frequent species were: C. albicans (61; 39.9%), C. parapsilosis (43; 27.6 %), C. tropicalis (36; 23.0%) and C. glabrata (8; 5.1%). Overall susceptibility rates were 98.0%, 98.7%, 98.0%, and 97.4% for amphotericin B, fluconazole, voriconazole and anidulafungin, respectively. No isolate was resistant to more than one drug. The results showed that the rate of resistance to 4 antifungal drugs was low among Candida bloodstream isolates in Lima, Peru. en_US
dc.subject Yeasts en_US
dc.subject Candidiasis en_US
dc.subject Candida albicans en_US
dc.subject Candida dubliniensis en_US
dc.subject Candida parapsilosis en_US
dc.subject Candida tropicalis en_US
dc.subject Candida glabrata en_US
dc.subject Identification en_US
dc.subject Species en_US
dc.subject Drug susceptibility en_US
dc.subject In vitro en_US
dc.subject Antifungal agents en_US
dc.subject Isolation en_US
dc.subject PCR en_US
dc.subject PCR-RFLP en_US
dc.subject Fluconazole en_US
dc.subject Anidulafungin en_US
dc.subject Voriconazole en_US
dc.subject Peru en_US
dc.subject America, Latin en_US
dc.title Species distribution and antifungal susceptibility profile of Candida isolates from bloodstream infections in Lima, Peru en_US
dc.type Article en_US
dc.citation.issue 6 en_US
dc.citation.jtitle Journal of Medical Microbiology en_US
dc.citation.volume 63 en_US
dc.citation.pages 855-860 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/24667770 en_US
dc.citation.jabbreviation J Med Microbiol en_US


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