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The burden of parasitic zoonoses in Nepal: a systematic review

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Show simple item record Devleesschauwer, B. en_US Ale, A. en_US Torgerson, P. en_US Praet, N. en_US Maertens de Noordhout, C. en_US Pandey, B. D. en_US Pun, S. B. en_US Lake, R. en_US Vercruysse, J. en_US Joshi, D. D. en_US Havelaar, A. H. en_US Duchateau, L. en_US Dorny, P. en_US Speybroeck, N. en_US 2014-09-25T13:39:45Z 2014-09-25T13:39:45Z 2014 en_US
dc.identifier.issn 1935-2727 en_US
dc.identifier.doi en_US
dc.identifier.other ITG-B4A; ITG-B13A; DBM; U-VHELM; JIF; DOI; FTA; E-only; OAJ; Abstract; UPD56 en_US
dc.description.abstract BACKGROUND: Parasitic zoonoses (PZs) pose a significant but often neglected threat to public health, especially in developing countries. In order to obtain a better understanding of their health impact, summary measures of population health may be calculated, such as the Disability-Adjusted Life Year (DALY). However, the data required to calculate such measures are often not readily available for these diseases, which may lead to a vicious circle of under-recognition and under-funding. METHODOLOGY: We examined the burden of PZs in Nepal through a systematic review of online and offline data sources. PZs were classified qualitatively according to endemicity, and where possible a quantitative burden assessment was conducted in terms of the annual number of incident cases, deaths and DALYs. PRINCIPAL FINDINGS: Between 2000 and 2012, the highest annual burden was imposed by neurocysticercosis and congenital toxoplasmosis (14,268 DALYs [95% Credibility Interval (CrI): 5450-27,694] and 9255 DALYs [95% CrI: 6135-13,292], respectively), followed by cystic echinococcosis (251 DALYs [95% CrI: 105-458]). Nepal is probably endemic for trichinellosis, toxocarosis, diphyllobothriosis, foodborne trematodosis, taeniosis, and zoonotic intestinal helminthic and protozoal infections, but insufficient data were available to quantify their health impact. Sporadic cases of alveolar echinococcosis, angiostrongylosis, capillariosis, dirofilariosis, gnathostomosis, sparganosis and cutaneous leishmaniosis may occur. CONCLUSIONS/SIGNIFICANCE: In settings with limited surveillance capacity, it is possible to quantify the health impact of PZs and other neglected diseases, thereby interrupting the vicious circle of neglect. In Nepal, we found that several PZs are endemic and are imposing a significant burden to public health, higher than that of malaria, and comparable to that of HIV/AIDS. However, several critical data gaps remain. Enhanced surveillance for the endemic PZs identified in this study would enable additional burden estimates, and a more complete picture of the impact of these diseases. en_US
dc.language English en_US
dc.subject Parasitic diseases en_US
dc.subject Zoonoses en_US
dc.subject Disease burden en_US
dc.subject Assessment en_US
dc.subject Health impact en_US
dc.subject Endemicity en_US
dc.subject DALYs en_US
dc.subject Morbidity en_US
dc.subject Mortality en_US
dc.subject Systematic review en_US
dc.subject Review of the literature en_US
dc.subject Nepal en_US
dc.subject Asia, South en_US
dc.title The burden of parasitic zoonoses in Nepal: a systematic review en_US
dc.type Article-E en_US
dc.citation.issue 1 en_US
dc.citation.jtitle PLoS Neglected Tropical Diseases en_US
dc.citation.volume 8 en_US
dc.citation.pages e2634 en_US
dc.identifier.pmid en_US
dc.citation.jabbreviation PLoS Negl Trop Dis en_US

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