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Two year mortality and associated factors in a cohort of children from rural Uganda

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dc.contributor.author Nabongo, P. en_US
dc.contributor.author Verver, S. en_US
dc.contributor.author Nangobi, E. en_US
dc.contributor.author Mutunzi, R. en_US
dc.contributor.author Wajja, A. en_US
dc.contributor.author Mayanja-Kizza, H. en_US
dc.contributor.author Kadobera, D. en_US
dc.contributor.author Galiwango, E. en_US
dc.contributor.author Colebunders, R. en_US
dc.contributor.author Musoke, P. en_US
dc.date.accessioned 2014-09-25T13:39:54Z
dc.date.available 2014-09-25T13:39:54Z
dc.date.issued 2014 en_US
dc.identifier.issn 1471-2458 en_US
dc.identifier.doi http://dx.doi.org/10.1186/1471-2458-14-314 en_US
dc.identifier.other ITG-C9A; DCS; U-HIVCLI; JIF; DOI; FTA; URL; OAJ; Abstract; UPD56 en_US
dc.identifier.uri http://hdl.handle.net/10390/7963
dc.description.abstract BACKGROUND: As part of site development for clinical trials in novel TB vaccines, a cohort of infants was enrolled in eastern Uganda to estimate the incidence of tuberculosis. The study introduced several mortality reduction strategies, and evaluated the mortality among study participants at two years. The specific of objective of this sub-study was to estimate 2 year mortality and associated factors in this community-based cohort. METHODS: A community based cohort of 2500 infants was enrolled from birth up to 8 weeks of age and followed for 1-2 years. During follow up, several mortality reduction activities were implemented to enhance cohort survival and retention. The verbal autopsy process was used to assign causes of death. RESULTS: A total of 152 children died over a median follow up period of 2.0 years. The overall crude mortality rate was 60.8/1000 or 32.9/1000 person years with 40 deaths per 1000 for children who died in their first year of life. Anaemia, malaria, diarrhoeal diseases and pneumonia were the top causes of death. There was no death directly attributed to tuberculosis. Significant factors associated with mortality were young age of a mother and child's birth place not being a health facility. CONCLUSION: The overall two year mortality in the study cohort was unacceptably high and tuberculosis disease was not identified as a cause of death. Interventions to reduce mortality of children enrolled in the cohort study did not have a significant impact. Clinical trials involving infants and young children in this setting will have to strengthen local maternal and child health services to reduce infant and child mortality. en_US
dc.language English en_US
dc.subject Bacterial diseases en_US
dc.subject Tuberculosis en_US
dc.subject Mycobacterium tuberculosis en_US
dc.subject Incidence en_US
dc.subject Mortality reduction en_US
dc.subject Mortality rates en_US
dc.subject Infants en_US
dc.subject Clinical trials en_US
dc.subject Causes of death en_US
dc.subject Verbal autopsy en_US
dc.subject Maternal health services en_US
dc.subject Child health services en_US
dc.subject Rural en_US
dc.subject Uganda en_US
dc.subject Africa, East en_US
dc.title Two year mortality and associated factors in a cohort of children from rural Uganda en_US
dc.type Article-E en_US
dc.citation.issue 314 en_US
dc.citation.jtitle BMC Public Health en_US
dc.citation.volume 14 en_US
dc.citation.pages 1-9 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/24708689 en_US
dc.identifier.url http://www.biomedcentral.com/1471-2458/14/314 en_US
dc.citation.jabbreviation BMC Public Health en_US


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