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Inbreeding within human Schistosoma mansoni: do host-specific factors shape the genetic composition of parasite populations?

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dc.contributor.author Van den Broeck, F. en_US
dc.contributor.author Meurs, L. en_US
dc.contributor.author Raeymaekers, J. A. en_US
dc.contributor.author Boon, N. en_US
dc.contributor.author Dieye, T. N. en_US
dc.contributor.author Volckaert, F. A. en_US
dc.contributor.author Polman, K. en_US
dc.contributor.author Huyse, T. en_US
dc.date.accessioned 2014-09-25T13:40:01Z
dc.date.available 2014-09-25T13:40:01Z
dc.date.issued 2014 en_US
dc.identifier.issn 0018-067X en_US
dc.identifier.doi http://dx.doi.org/10.1038/hdy.2014.13 en_US
dc.identifier.other ITG-B1B; ITG-B2B; ITG-B4B; ITG-B7A; ITG-BLB; DBM; U-MYCOB; JIF; DOI; Abstract; UPD56 en_US
dc.identifier.uri http://hdl.handle.net/10390/8044
dc.description.abstract The size, structure and distribution of host populations are key determinants of the genetic composition of parasite populations. Despite the evolutionary and epidemiological merits, there has been little consideration of how host heterogeneities affect the evolutionary trajectories of parasite populations. We assessed the genetic composition of natural populations of the parasite Schistosoma mansoni in northern Senegal. A total of 1346 parasites were collected from 14 snail and 57 human hosts within three villages and individually genotyped using nine microsatellite markers. Human host demographic parameters (age, gender and village of residence) and co-infection with Schistosoma haematobium were documented, and S. mansoni infection intensities were quantified. F-statistics and clustering analyses revealed a random distribution (panmixia) of parasite genetic variation among villages and hosts, confirming the concept of human hosts as 'genetic mixing bowls' for schistosomes. Host gender and village of residence did not show any association with parasite genetics. Host age, however, was significantly correlated with parasite inbreeding and heterozygosity, with children being more infected by related parasites than adults. The patterns may be explained by (1) genotype-dependent 'concomitant immunity' that leads to selective recruitment of genetically unrelated worms with host age, and/or (2) the 'genetic mixing bowl' hypothesis, where older hosts have been exposed to a wider variety of parasite strains than children. The present study suggests that host-specific factors may shape the genetic composition of schistosome populations, revealing important insights into host-parasite interactions within a natural system. Heredity advance online publication, 12 March 2014. en_US
dc.language English en_US
dc.subject Helminthic diseases en_US
dc.subject Schistosomiasis en_US
dc.subject Schistosoma mansoni en_US
dc.subject Schistosoma haematobium en_US
dc.subject Hosts en_US
dc.subject Snails en_US
dc.subject Determinants en_US
dc.subject Genetic diversity en_US
dc.subject Heterogeneity en_US
dc.subject Genotyping en_US
dc.subject Age en_US
dc.subject Gender en_US
dc.subject Infection intensity en_US
dc.subject Distribution en_US
dc.subject Associations en_US
dc.subject Correlation en_US
dc.subject Concomitant infections en_US
dc.subject Senegal en_US
dc.subject Africa, West en_US
dc.title Inbreeding within human Schistosoma mansoni: do host-specific factors shape the genetic composition of parasite populations? en_US
dc.type Article en_US
dc.citation.issue 1 en_US
dc.citation.jtitle Heredity en_US
dc.citation.volume 113 en_US
dc.citation.pages 32-41 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/24619176 en_US
dc.citation.jabbreviation Heredity (Edinb.) en_US


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