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A phase III trial to evaluate the efficacy, fabric integrity and community acceptance of Netprotect using a recommended long-lasting insecticidal net as positive control

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Show simple item record Van Roey, K. en_US Sovannaroth, S. en_US Sochantha, T. en_US Touch, M. S. en_US Pigeon, O. en_US Sluydts, V. en_US Durnez, L. en_US Coosemans, M. en_US 2014-09-25T13:40:03Z 2014-09-25T13:40:03Z 2014 en_US
dc.identifier.issn 1475-2875 en_US
dc.identifier.doi en_US
dc.identifier.other ITG-B1B; ITG-B6B; ITG-B7A; ITG-BLA; DBM; U-ENTOM; JIF; DOI; FTA; E-only; OAJ; Abstract; UPD56 en_US
dc.description.abstract BACKGROUND: The evaluation of new long-lasting insecticidal bed nets (LLINs) is coordinated by the WHO Pesticide Evaluation Scheme (WHOPES). In 2007, Netprotect(R) was granted WHOPES interim recommendation after Phase I and II evaluations. Present study evaluates Netprotect in a Phase III trial in rural Cambodia. METHODS: A randomized, prospective longitudinal study design was used to assess the performance of Netprotect over a period of three years, using conventionally-treated nets and a WHOPES recommended LLIN (PermaNet 2.0) as positive controls. The primary outcomes were the physical integrity, insecticide content and cone bioassay performance using. RESULTS: The baseline deltamethrin concentration of 43% of Netprotect nets were below the tolerance limit while 27% of PermaNet 2.0 nets were above the target dose limits. By 36 months Netprotect retained 35% while PermaNet 2.0 retained 49% of baseline insecticide dose. Moreover the proportion of the inactive deltamethrin R-alpha isomer in the Netprotect nets was 33% at the baseline and increased to 69% after three years while it was low and almost constant for PermaNet(R) 2.0 (3-7%). Only 71% of Netprotect met the WHO criteria for bio-efficacy after three years while at least 80% is required. Moreover Netprotect nets failed for the WHOPES criteria after 12 and 24 months. The reference LLIN met the WHOPES criteria throughout the study. Over the entire three years the reference LLIN did obtain significant higher mosquito mortality than Netprotect. The physical integrity was based on the proportionate hole index and after three years, 25% of Netprotect and 30% of PermaNet 2.0 were in a mediocre or poor state. CONCLUSION: Netprotect did not meet the minimum WHO criteria for bio-efficacy after 12, 24 and 36 months. The use of a reference LLIN as positive control was helpful for data interpretation. However, for future three-year studies, it is essential that before initiating any study nets should be checked for their specifications and this for both the candidate LLIN as well as for the reference LLIN. Moreover, to improve the accuracy of the success rate of the candidate LLIN more nets should be tested for their bio-efficacy at the end of the trial. en_US
dc.language English en_US
dc.subject Protozoal diseases en_US
dc.subject Malaria en_US
dc.subject Plasmodium falciparum en_US
dc.subject Vectors en_US
dc.subject Mosquitoes en_US
dc.subject Anopheles en_US
dc.subject Vector control en_US
dc.subject Impregnated bednets en_US
dc.subject Long-lasting nets en_US
dc.subject Insecticides en_US
dc.subject Deltamethrin en_US
dc.subject Evaluation en_US
dc.subject Performance en_US
dc.subject Efficacy en_US
dc.subject Acceptability en_US
dc.subject Community-based en_US
dc.subject Clinical trials en_US
dc.subject Rural en_US
dc.subject Cambodia en_US
dc.subject Asia, Southeast en_US
dc.title A phase III trial to evaluate the efficacy, fabric integrity and community acceptance of Netprotect using a recommended long-lasting insecticidal net as positive control en_US
dc.type Article-E en_US
dc.citation.issue 256 en_US
dc.citation.jtitle Malaria Journal en_US
dc.citation.volume 13 en_US
dc.citation.pages 1-11 en_US
dc.identifier.pmid en_US
dc.citation.jabbreviation Malar J en_US

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