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Risk factors for the development and severity of juvenile-onset recurrent respiratory papillomatosis: A systematic review

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dc.contributor.author Niyibizi, J.
dc.contributor.author Rodier, C.
dc.contributor.author Wassef, M.
dc.contributor.author Trottier, H.
dc.date.accessioned 2014-12-08T10:26:33Z
dc.date.available 2014-12-08T10:26:33Z
dc.date.issued 2014
dc.identifier.doi http://dx.doi.org/10.1016/j.ijporl.2013.11.036
dc.identifier.uri http://hdl.handle.net/10390/8174
dc.description.abstract Objectives: Juvenile-onset recurrent respiratory papillomatosis (JoRRP) is a rare yet aggressive disease caused by human papillomavirus (HPV). Although many newborns are likely exposed to HPV, few develop JoRRP and the clinical course of the disease varies from one child to another. This systematic review seeks to provide an up-to-date understanding of the risk factors for acquisition and severity. Methods: We conducted a comprehensive literature search in EMBASE, MEDLINE and EBMR databases using various combinations of keywords related to JoRRP etiology, risk factors and severity. We also searched Google Scholar and the reference lists of eligible studies. Our search was limited to original studies published in French or English between 1995 and July 2012 and to patients under 20 years of age. Results: Of 1362 citations, we retrieved 102 articles and found 14 additional studies. We retained 32 studies meeting inclusion criteria. All were observational and together included 2296 JoRRP cases. Risk factors could be classified mainly as maternal and birth history, viral genotype, and host factors. A history of genital warts during pregnancy and delivery was strongly linked to the development of JoRRP. Depending on ethnicity, specific human leukocyte antigen class II alleles and immune response factors were important determinants of JoRRP acquisition and severity. HPV-11 genotype and younger age at onset of JoRRP were important predictors of severity. Conclusions: Genetic and immunological profiles underlying the acquisition and clinical course are not readily modifiable. Thus, preventing condylomas in women of childbearing age could reduce the burden of this life-threatening disease. en_US
dc.language English en_US
dc.publisher Elsevier Ireland Ltd. en_US
dc.subject Human papillomavirus en_US
dc.subject Recurrent respiratory papillomatosis en_US
dc.subject Acquisition en_US
dc.subject Severity en_US
dc.subject Review en_US
dc.title Risk factors for the development and severity of juvenile-onset recurrent respiratory papillomatosis: A systematic review en_US
dc.type Article-E en_US
dc.citation.jtitle Elsevier en_US
dc.citation.volume 78 en_US
dc.citation.pages 186-197 en_US
dc.citation.jabbreviation Elsevier en_US


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