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Prevalence and correlates of bacterial vaginosis in different sub-populations of women in sub-saharan Africa: a cross-sectional study

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dc.contributor.author Jespers, V.
dc.contributor.author Crucitti, T.
dc.contributor.author Menten, J.
dc.contributor.author Verhelst, R.
dc.contributor.author Mwaura, M.
dc.contributor.author Mandaliya, K.
dc.contributor.author Ndayisaba, G. F.
dc.contributor.author Delany-Moretlwe, S.
dc.contributor.author Verstraelen, H.
dc.contributor.author Hardy, L.
dc.contributor.author Buvé, A.
dc.contributor.author van de Wijgert, J.
dc.date.accessioned 2015-01-23T15:09:38Z
dc.date.available 2015-01-23T15:09:38Z
dc.date.issued 2014
dc.identifier.issn 1932-6203
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0109670
dc.identifier.other ITG-H1B
dc.identifier.other ITG-C2A
dc.identifier.other ITG-C3A
dc.identifier.other ITG-H10B
dc.identifier.other ITG-H11A
dc.identifier.other MULTI
dc.identifier.other DPH
dc.identifier.other U-ECHIV
dc.identifier.other DCS
dc.identifier.other U-ARLAB
dc.identifier.other U-CTU
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other FTA
dc.identifier.other E-only
dc.identifier.other OAJ
dc.identifier.other Abstract
dc.identifier.other UPD57
dc.identifier.uri http://hdl.handle.net/10390/8218
dc.description.abstract BACKGROUND: Clinical development of vaginally applied products aimed at reducing the transmission of HIV and other sexually transmitted infections, has highlighted the need for a better characterisation of the vaginal environment. We set out to characterise the vaginal environment in women in different settings in sub-Saharan Africa. METHODS: A longitudinal study was conducted in Kenya, Rwanda and South-Africa. Women were recruited into pre-defined study groups including adult, non-pregnant, HIV-negative women; pregnant women; adolescent girls; HIV-negative women engaging in vaginal practices; female sex workers; and HIV-positive women. Consenting women were interviewed and underwent a pelvic exam. Samples of vaginal fluid and a blood sample were taken and tested for bacterial vaginosis (BV), HIV and other reproductive tract infections (RTIs). This paper presents the cross-sectional analyses of BV Nugent scores and RTI prevalence and correlates at the screening and the enrolment visit. RESULTS: At the screening visit 38% of women had BV defined as a Nugent score of 7-10, and 64% had more than one RTI (N. gonorrhoea, C. trachomatis, T. vaginalis, syphilis) and/or Candida. At screening the likelihood of BV was lower in women using progestin-only contraception and higher in women with more than one RTI. At enrolment, BV scores were significantly associated with the presence of prostate specific antigen (PSA) in the vaginal fluid and with being a self-acknowledged sex worker. Further, sex workers were more likely to have incident BV by Nugent score at enrolment. CONCLUSIONS: Our study confirmed some of the correlates of BV that have been previously reported but the most salient finding was the association between BV and the presence of PSA in the vaginal fluid which is suggestive of recent unprotected sexual intercourse. en_US
dc.language English en_US
dc.subject Bacterial diseases en_US
dc.subject Vaginosis en_US
dc.subject Women en_US
dc.subject Vagina en_US
dc.subject Prevalence en_US
dc.subject Screening en_US
dc.subject Characterization en_US
dc.subject Reproductive disorders en_US
dc.subject Vaginal flora en_US
dc.subject Associations en_US
dc.subject Prostate specific antigen (PSA) en_US
dc.subject Kenya en_US
dc.subject Africa, East en_US
dc.subject Rwanda en_US
dc.subject Africa, Central en_US
dc.subject South Africa en_US
dc.subject Africa, Southern en_US
dc.title Prevalence and correlates of bacterial vaginosis in different sub-populations of women in sub-saharan Africa: a cross-sectional study en_US
dc.type Article-E en_US
dc.citation.issue 10 en_US
dc.citation.jtitle PLoS ONE en_US
dc.citation.volume 9 en_US
dc.citation.pages e109670 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/25289640
dc.citation.jabbreviation PLoS ONE en_US


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