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In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin piperaquine in Burkina Faso

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In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin piperaquine in Burkina Faso

Baraka, V.; Tinto, H.; Valea, I.; Fitzhenry, R.; Delgado-Ratto, C.; Mbonye, M. K.; Van Overmeir, C.; Rosanas-Urgell, A.; Van geertruyden, J. P.; D'Alessandro, U.; Erhart, A.
Journal Name:
Antimicrobial Agents and Chemotherapy
Issue Date:
2015
Volume:
59
Issue:
1
Pages:
734-737
DOI:
http://dx.doi.org/10.1128/AAC.03647-14
Pubmed ID:
http://www.ncbi.nlm.nih.gov/pubmed/25403659
Language:
English
Type:
Article
Keywords:
Protozoal diseases
Malaria
Plasmodium falciparum
Vectors
Mosquitoes
Anopheles
Combination therapy
Children
Artemether-lumefantrine
Dihydroartemisinin-piperaquine
In vivo
Pfcrt
Pfmdr-1
Polymorphism
Burkina Faso
Africa, West

Abstract:

Plasmodium falciparum Pfcrt-76 and Pfmdr1-86 gene polymorphisms were determined during a clinical trial in Burkina Faso comparing the efficacy of dihydroartemisinin-piperaquine (DHA-PPQ) and artemether-lumefantrine (AL). A significant selection of Pfcrt-K76 was observed after exposure to AL and DHA-PPQ, as well as of Pfmdr1-N86 after AL but not after DHA-PPQ treatment, suggesting a reverse selection on the Pfcrt gene by PPQ. These results support the rational use of DHA-PPQ in settings where CQ resistance is high.

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