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Anti-Trichinella IgG in ethnic minorities living in Trichinella-endemic areas in Northwest Vietnam: study of the predictive value of selected clinical signs and symptoms for the diagnosis of trichinellosis

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dc.contributor.author Nga, V. T.
dc.contributor.author Pozio, E.
dc.contributor.author De, N. V.
dc.contributor.author Praet, N.
dc.contributor.author Pezzotti, P.
dc.contributor.author Gabriël, S.
dc.contributor.author Claes, M.
dc.contributor.author Thuy, N. T.
dc.contributor.author Dorny, P.
dc.date.accessioned 2015-02-10T15:00:14Z
dc.date.available 2015-02-10T15:00:14Z
dc.date.issued 2014
dc.identifier.issn 0001-706X
dc.identifier.doi http://dx.doi.org/10.1016/j.actatropica.2014.07.012
dc.identifier.other ITG-B4A
dc.identifier.other ITG-B6A
dc.identifier.other ITG-B7B
dc.identifier.other ITG-BLA
dc.identifier.other DBM
dc.identifier.other U-VHELM
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other Abstract
dc.identifier.other UPD57
dc.identifier.uri http://hdl.handle.net/10390/8261
dc.description.abstract The objective of this study was to assess the presence of anti-Trichinella IgG in the serum of persons from ethnic minorities from northwest Vietnam with clinical signs and symptoms that are compatible with trichinellosis. A total of 645 persons were enrolled, of which 200 people lived in two villages where outbreaks of human trichinellosis had been documented in 2004 and 2008, and 445 people who were hospitalized in the Dien Bien and Son La provincial hospitals without a definitive diagnosis. Presence of anti-Trichinella IgG was demonstrated in serum samples by a standardized Enzyme-linked Immunosorbant Assay (ELISA); positive serum samples were subjected to Western Blot (WB) for confirmation. Seven (3.5%; 95% CI: 1.4 - 7.1) persons from the villages and seven (1.6%; 95% CI: 0.6 - 3.2) hospitalized patients, tested positive by both ELISA and WB. Fever (N=13), eosinophilia (N=12), myalgia (N=9), facial oedema (N=9) and leukocytosis (N=8) were the most common clinical signs and symptoms in the serologically positive persons. The concomitant occurrence of facial oedema and myalgia among the enrolled persons from the villages, accounted for 75% of the positive predictive value (PPV) and 99.5% of the negative predictive value (NPV), suggesting that they could be used for suspecting trichinellosis when serology is not available. The high prevalence (1.6 - 3.5%) of anti-Trichinella IgG in persons from Vietnamese provinces where T. spiralis is circulating in pigs strongly supports the need to develop control programmes to eliminate the infection from pigs and for consumers' education and protection. en_US
dc.language English en_US
dc.subject Helminthic diseases en_US
dc.subject Zoonoses en_US
dc.subject Trichinellosis en_US
dc.subject Trichinella en_US
dc.subject Pigs en_US
dc.subject Prevalence en_US
dc.subject Diagnosis en_US
dc.subject Clinical manifestations en_US
dc.subject Signs and symptoms en_US
dc.subject Predictive value en_US
dc.subject Fever en_US
dc.subject Eosinophilia en_US
dc.subject Myalgia en_US
dc.subject Detection en_US
dc.subject IgG en_US
dc.subject Serology en_US
dc.subject Ethnic groups en_US
dc.subject Vietnam en_US
dc.subject Asia, Southeast en_US
dc.title Anti-Trichinella IgG in ethnic minorities living in Trichinella-endemic areas in Northwest Vietnam: study of the predictive value of selected clinical signs and symptoms for the diagnosis of trichinellosis en_US
dc.type Article en_US
dc.citation.jtitle Acta Tropica en_US
dc.citation.volume 139 en_US
dc.citation.pages 93-98 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/25076109
dc.citation.jabbreviation Acta Trop en_US


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