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Geographical segregation of Cryptosporidium parvum multilocus genotypes in Europe

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Show simple item record Cacciò, S. M. De Waele, V. Widmer, G. 2015-08-05T14:49:59Z 2015-08-05T14:49:59Z 2015
dc.identifier.issn 1567-1348
dc.identifier.other ITG-B2B
dc.identifier.other DBM
dc.identifier.other U-VEPID
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other Abstract
dc.identifier.other UPD58
dc.description.abstract Cryptosporidium parvum is a common enteric protozoan pathogen of humans and livestock. Multilocus genotyping based on simple sequence repeat polymorphisms has been used extensively to identify transmission cycles and to investigate the structure of C. parvum populations and of the related pathogen Cryptosporidiumhominis. Using such methods, the zoonotic transmission of C. parvum has been shown to be epidemiologically important. Because different genetic markers have been used in different surveys, the comparison of Cryptosporidium genotypes across different laboratories is often not feasible. Therefore, few comparisons of Cryptosporidium populations across wide geographical areas have been published and our understanding of the epidemiology of cryptosporidiosis is fragmented. Here we report on the genotypic analysis of a large collection of 692 C. parvum isolates originating primarily from cattle and other ruminants from Italy, Ireland and Scotland. Because the same genotypic markers were used in these surveys, it was possible to merge the data. We found significant geographical segregation and a correlation between genetic and geographic distance, consistent with a model of isolation by distance. The presence of strong LD and positive IAS values in the combined MLG dataset suggest departure from panmixia, with different population structures of the parasite prevailing in each country. en_US
dc.language English en_US
dc.subject Animal diseases en_US
dc.subject Zoonoses en_US
dc.subject Protozoal diseases en_US
dc.subject Cryptosporidiosis en_US
dc.subject Cryptosporidium parvum en_US
dc.subject Enteric infections en_US
dc.subject Cattle en_US
dc.subject Multilocus en_US
dc.subject Genotyping en_US
dc.subject Comparative study en_US
dc.subject Geographical variation en_US
dc.subject Population structure en_US
dc.subject Markers en_US
dc.subject Segregation en_US
dc.subject Distance en_US
dc.subject Italy en_US
dc.subject Europe, South en_US
dc.subject Ireland en_US
dc.subject Scotland en_US
dc.subject Europe, West en_US
dc.title Geographical segregation of Cryptosporidium parvum multilocus genotypes in Europe en_US
dc.type Article en_US
dc.citation.issue C en_US
dc.citation.jtitle Infection, Genetics and Evolution en_US
dc.citation.volume 31 en_US
dc.citation.pages 245-249 en_US
dc.citation.jabbreviation Infect Genet Evol en_US

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