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Field evaluation of picaridin repellents reveals differences in repellent sensitivity between Southeast Asian vectors of malaria and arboviruses

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dc.contributor.author Van Roey, K.
dc.contributor.author Sokny, M.
dc.contributor.author Denis, L.
dc.contributor.author Van den Broeck, N.
dc.contributor.author Heng, S.
dc.contributor.author Siv, S.
dc.contributor.author Sluydts, V.
dc.contributor.author Sochantha, T.
dc.contributor.author Coosemans, M.
dc.contributor.author Durnez, L.
dc.date.accessioned 2015-08-19T12:42:58Z
dc.date.available 2015-08-19T12:42:58Z
dc.date.issued 2014
dc.identifier.issn 1935-2727
dc.identifier.doi http://dx.doi.org/10.1371/journal.pntd.0003326
dc.identifier.other ITG-B1B
dc.identifier.other ITG-B3B
dc.identifier.other ITG-B4B
dc.identifier.other ITG-B7B
dc.identifier.other ITG-B9A
dc.identifier.other ITG-BLA
dc.identifier.other DBM
dc.identifier.other U-ENTOM
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other FTA
dc.identifier.other E-only
dc.identifier.other OAJ
dc.identifier.other Abstract
dc.identifier.other UPD58
dc.identifier.uri http://hdl.handle.net/10390/8415
dc.description.abstract Scaling up of insecticide treated nets has contributed to a substantial malaria decline. However, some malaria vectors, and most arbovirus vectors, bite outdoors and in the early evening. Therefore, topically applied insect repellents may provide crucial additional protection against mosquito-borne pathogens. Among topical repellents, DEET is the most commonly used, followed by others such as picaridin. The protective efficacy of two formulated picaridin repellents against mosquito bites, including arbovirus and malaria vectors, was evaluated in a field study in Cambodia. Over a period of two years, human landing collections were performed on repellent treated persons, with rotation to account for the effect of collection place, time and individual collector. Based on a total of 4996 mosquitoes collected on negative control persons, the overall five hour protection rate was 97.4% [95%CI: 97.1-97.8%], not decreasing over time. Picaridin 20% performed equally well as DEET 20% and better than picaridin 10%. Repellents performed better against Mansonia and Culex spp. as compared to aedines and anophelines. A lower performance was observed against Aedes albopictus as compared to Aedes aegypti, and against Anopheles barbirostris as compared to several vector species. Parity rates were higher in vectors collected on repellent treated person as compared to control persons. As such, field evaluation shows that repellents can provide additional personal protection against early and outdoor biting malaria and arbovirus vectors, with excellent protection up to five hours after application. The heterogeneity in repellent sensitivity between mosquito genera and vector species could however impact the efficacy of repellents in public health programs. Considering its excellent performance and potential to protect against early and outdoor biting vectors, as well as its higher acceptability as compared to DEET, picaridin is an appropriate product to evaluate the epidemiological impact of large scale use of topical repellents on arthropod borne diseases. en_US
dc.language English en_US
dc.subject Protozoal diseases en_US
dc.subject Malaria en_US
dc.subject Plasmodium falciparum en_US
dc.subject Arboviruses en_US
dc.subject Vectors en_US
dc.subject Mosquitoes en_US
dc.subject Anopheles en_US
dc.subject Aedes en_US
dc.subject Vector control en_US
dc.subject Repellents en_US
dc.subject Sensitivity en_US
dc.subject Evaluation en_US
dc.subject Field research en_US
dc.subject Differences en_US
dc.subject Picaridin en_US
dc.subject DEET en_US
dc.subject Bites en_US
dc.subject Cambodia en_US
dc.subject Asia, Southeast en_US
dc.title Field evaluation of picaridin repellents reveals differences in repellent sensitivity between Southeast Asian vectors of malaria and arboviruses en_US
dc.type Article-E en_US
dc.citation.issue 12 en_US
dc.citation.jtitle PLoS Neglected Tropical Diseases en_US
dc.citation.volume 8 en_US
dc.citation.pages e3326 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/25522134
dc.citation.jabbreviation PLoS Negl Trop Dis en_US


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