Institute of Tropical Medicine Antwerp
Foundation of Public Utility

Estimation of canine Leishmania infection prevalence in six cities of the Algerian littoral zone using a bayesian approach

DSpace/Manakin Repository

Show simple item record Adel, A. Abatih, E. Speybroeck, N. Soukehal, A. Bouguedour, R. Boughalem, K. Bouhbal, A. Djerbal, M. Saegerman, C. Berkvens, D. 2015-08-20T14:34:08Z 2015-08-20T14:34:08Z 2015
dc.identifier.issn 1932-6203
dc.identifier.other ITG-B1B
dc.identifier.other ITG-B2B
dc.identifier.other ITG-BLA
dc.identifier.other DBM
dc.identifier.other U-VEPID
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other FTA
dc.identifier.other OAJ
dc.identifier.other Abstract
dc.identifier.other UPD59
dc.description.abstract A large-scale study on canine Leishmania infection (CanL) was conducted in six localities along a west-east transect in the Algerian littoral zone (Tlemcen, Mostaganem, Tipaza, Boumerdes, Bejaia, Jijel) and covering two sampling periods. In total 2,184 dogs were tested with an indirect fluorescent antibody test (IFAT) and a direct agglutination test (DAT). Combined multiple-testing and several statistical methods were compared to estimate the CanL true prevalence and tests characteristics (sensitivity and specificity). The Bayesian full model showed the best fit and yielded prevalence estimates between 11% (Mostaganem, first period) and 38% (Bejaia, second period). Sensitivity of IFAT varied (in function of locality) between 86% and 88% while its specificity varied between 65% and 87%. DAT was less sensitive than IFAT but showed a higher specificity (between 80% and 95% in function of locality or/and season). A general increasing trend of the CanL prevalence was noted from west to east. A concordance between the present results and the incidence of human cases of visceral leishmaniasis was observed, where also a maximum was recorded for Bejaia. The results of the present study highlight the dangers when using IFAT as a gold standard. en_US
dc.language English en_US
dc.subject Protozoal diseases en_US
dc.subject Animal en_US
dc.subject Canine en_US
dc.subject Leishmaniasis en_US
dc.subject Leishmania en_US
dc.subject Sandflies en_US
dc.subject Phlebotomus perniciosus en_US
dc.subject Phlebotomus longicuspis en_US
dc.subject Dogs en_US
dc.subject Prevalence en_US
dc.subject Epidemiology en_US
dc.subject Estimation en_US
dc.subject IFAT en_US
dc.subject Direct agglutination test en_US
dc.subject DAT en_US
dc.subject Specificity en_US
dc.subject Sensitivity en_US
dc.subject Algeria en_US
dc.subject Africa, North en_US
dc.title Estimation of canine Leishmania infection prevalence in six cities of the Algerian littoral zone using a bayesian approach en_US
dc.type Article-E en_US
dc.citation.issue 3 en_US
dc.citation.jtitle PLoS ONE en_US
dc.citation.volume 10 en_US
dc.citation.pages e0117313 en_US
dc.citation.jabbreviation PLoS ONE en_US

Files in this item

This item appears in the following Collection(s)

Show simple item record