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Injectable progestin-only contraception is asociated with increased levels of pro-inflammatory cytokines in the female genital tract

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dc.contributor.author Deese, J.
dc.contributor.author Masson, L.
dc.contributor.author Miller, W.
dc.contributor.author Cohen, M.
dc.contributor.author Morrison, C.
dc.contributor.author Wang, M.
dc.contributor.author Ahmed, K.
dc.contributor.author Agot, K.
dc.contributor.author Crucitti, T.
dc.contributor.author Abdellati, S.
dc.contributor.author Van Damme, L.
dc.date.accessioned 2016-01-14T13:46:34Z
dc.date.available 2016-01-14T13:46:34Z
dc.date.issued 2015
dc.identifier.issn 1046-7408
dc.identifier.doi http://dx.doi.org/10.1111/aji.12415
dc.identifier.other ITG-C9A
dc.identifier.other ITG-C10A
dc.identifier.other DCS
dc.identifier.other U-ARLAB
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other Abstract
dc.identifier.other UPD60
dc.identifier.other NOBIT
dc.identifier.uri http://hdl.handle.net/10390/8604
dc.description.abstract PROBLEM: Genital inflammatory changes may be a mechanism of increased HIV risk among injectable progestin-only contraception (IPC) users. METHOD OF STUDY: We conducted a cross-sectional analysis of 376 Kenyan and South African women. Genital cytokines and secretory leukocyte peptidase inhibitor concentrations in a reference population were compared to IPC users and women with reproductive tract infections. RESULTS: No significant variability in marker concentrations was observed by age or site. Depot medroxyprogesterone acetate (DMPA) users had significantly higher MIP-1alpha, MIP-1beta, IL-6, IL-8, IP-10, and RANTES concentrations. Norethisterone oenanthate users had significantly higher IL-6, IL-8, and RANTES concentrations. Women with sexually transmitted infections had variable inflammation, and women with bacterial vaginosis exhibited a mixed profile of up and downregulation. CONCLUSION: The finding of substantial mucosal inflammation among DMPA users provides evidence which, combined with the results of prior studies, suggests that DMPA may create an immune environment conducive to HIV target cell recruitment and inhibitory for antiviral activity. en_US
dc.language English en_US
dc.subject Women's health en_US
dc.subject Sexually transmitted diseases en_US
dc.subject STD en_US
dc.subject Women en_US
dc.subject Reproductive health en_US
dc.subject Genital tract infections en_US
dc.subject Inflammation en_US
dc.subject Cytokine production en_US
dc.subject Associations en_US
dc.subject Progesterone en_US
dc.subject Contraception en_US
dc.subject Injections en_US
dc.subject Kenya en_US
dc.subject Africa, East en_US
dc.subject South Africa en_US
dc.subject Africa, Southern en_US
dc.title Injectable progestin-only contraception is asociated with increased levels of pro-inflammatory cytokines in the female genital tract en_US
dc.type Article en_US
dc.citation.issue 4 en_US
dc.citation.jtitle American Journal of Reproductive Immunology en_US
dc.citation.volume 74 en_US
dc.citation.pages 347-367 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/26202107
dc.citation.jabbreviation Am J Reprod Immunol en_US


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