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Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain >/=14 days): Pierrea multi-country, prospective, non-experimental case-control study

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dc.contributor.author Polman, K.
dc.contributor.author Becker, S. L.
dc.contributor.author Alirol, E.
dc.contributor.author Bhatta, N. K.
dc.contributor.author Bhattarai, N. R.
dc.contributor.author Bottieau, E.
dc.contributor.author Bratschi, M. W.
dc.contributor.author Burza, S.
dc.contributor.author Coulibaly, J. T.
dc.contributor.author Doumbia, M. N.
dc.contributor.author Horie, N. S.
dc.contributor.author Jacobs, J.
dc.contributor.author Khanal, B.
dc.contributor.author Landoure, A.
dc.contributor.author Mahendradhata, Y.
dc.contributor.author Meheus, F.
dc.contributor.author Mertens, P.
dc.contributor.author Meyanti, F.
dc.contributor.author Murhandarwati, E. H.
dc.contributor.author N'Goran, E. K.
dc.contributor.author Peeling, R. W.
dc.contributor.author Ravinetto, R.
dc.contributor.author Rijal, S.
dc.contributor.author Sacko, M.
dc.contributor.author Saye, R.
dc.contributor.author Schneeberger, P. H.
dc.contributor.author Schurmans, C.
dc.contributor.author Silue, K. D.
dc.contributor.author Thobari, J. A.
dc.contributor.author Traore, M. S.
dc.contributor.author van Lieshout, L.
dc.contributor.author van Loen, H.
dc.contributor.author Verdonck, K.
dc.contributor.author von Müller, L.
dc.contributor.author Yansouni, C. P.
dc.contributor.author Yao, J. A.
dc.contributor.author Yao, P. K.
dc.contributor.author Yap, P.
dc.contributor.author Boelaert, M.
dc.contributor.author Chappuis, F.
dc.contributor.author Utzinger, J.
dc.date.accessioned 2016-01-15T14:04:23Z
dc.date.available 2016-01-15T14:04:23Z
dc.date.issued 2015
dc.identifier.issn 1471-2334
dc.identifier.doi http://dx.doi.org/10.1186/s12879-015-1074-x
dc.identifier.other ITG-B1A
dc.identifier.other ITG-C6A
dc.identifier.other ITG-C12A
dc.identifier.other ITG-C22A
dc.identifier.other ITG-C27B
dc.identifier.other ITG-C32B
dc.identifier.other ITG-H33A
dc.identifier.other ITG-H39A
dc.identifier.other MULTI-3
dc.identifier.other DBM
dc.identifier.other U-MHELM
dc.identifier.other DCS
dc.identifier.other U-TROPIC
dc.identifier.other U-TLM
dc.identifier.other U-CTU
dc.identifier.other DPH
dc.identifier.other U-ECTD
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other FTA
dc.identifier.other URL
dc.identifier.other OAJ
dc.identifier.other Abstract
dc.identifier.other UPD60
dc.identifier.uri http://hdl.handle.net/10390/8617
dc.description.abstract BACKGROUND: Diarrhoea still accounts for considerable mortality and morbidity worldwide. The highest burden is concentrated in tropical areas where populations lack access to clean water, adequate sanitation and hygiene. In contrast to acute diarrhoea (<14 days), the spectrum of pathogens that may give rise to persistent diarrhoea (>/=14 days) and persistent abdominal pain is poorly understood. It is conceivable that pathogens causing neglected tropical diseases play a major role, but few studies investigated this issue. Clinical management and diagnostic work-up of persistent digestive disorders in the tropics therefore remain inadequate. Hence, important aspects regarding the pathogenesis, epidemiology, clinical symptomatology and treatment options for patients presenting with persistent diarrhoea and persistent abdominal pain should be investigated in multi-centric clinical studies. METHODS/DESIGN: This multi-country, prospective, non-experimental case-control study will assess persistent diarrhoea (>/=14 days; in individuals aged >/=1 year) and persistent abdominal pain (>/=14 days; in children/adolescents aged 1-18 years) in up to 2000 symptomatic patients and 2000 matched controls. Subjects from Cote d'Ivoire, Indonesia, Mali and Nepal will be clinically examined and interviewed using a detailed case report form. Additionally, each participant will provide a stool sample that will be examined using a suite of diagnostic methods (i.e., microscopic techniques, rapid diagnostic tests, stool culture and polymerase chain reaction) for the presence of bacterial and parasitic pathogens. Treatment will be offered to all infected participants and the clinical treatment response will be recorded. Data obtained will be utilised to develop patient-centred clinical algorithms that will be validated in primary health care centres in the four study countries in subsequent studies. DISCUSSION: Our research will deepen the understanding of the importance of persistent diarrhoea and related digestive disorders in the tropics. A diversity of intestinal pathogens will be assessed for potential associations with persistent diarrhoea and persistent abdominal pain. Different diagnostic methods will be compared, clinical symptoms investigated and diagnosis-treatment algorithms developed for validation in selected primary health care centres. The findings from this study will improve differential diagnosis and evidence-based clinical management of digestive syndromes in the tropics. TRIAL REGISTRATION: ClinicalTrials.gov; identifier: NCT02105714. en_US
dc.language English en_US
dc.subject Neglected diseases en_US
dc.subject Bacterial diseases en_US
dc.subject Protozoal diseases en_US
dc.subject Diarrhea en_US
dc.subject Persistent en_US
dc.subject Abdominal pain en_US
dc.subject Diagnosis en_US
dc.subject Treatment en_US
dc.subject Diagnostics en_US
dc.subject Protocols en_US
dc.subject Algorithms en_US
dc.subject Multilocus en_US
dc.subject Quality improvement en_US
dc.subject Case-control studies en_US
dc.subject Côte d'Ivoire en_US
dc.subject Mali en_US
dc.subject Africa, West en_US
dc.subject Nepal en_US
dc.subject Asia, South en_US
dc.subject Indonesia en_US
dc.subject Asia, Southeast en_US
dc.title Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain >/=14 days): Pierrea multi-country, prospective, non-experimental case-control study en_US
dc.type Article-E en_US
dc.citation.issue 338 en_US
dc.citation.jtitle BMC Infectious Diseases en_US
dc.citation.volume 15 en_US
dc.citation.pages 1-13 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/26282537
dc.citation.jabbreviation BMC Infect Dis en_US


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