Institute of Tropical Medicine Antwerp
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Salmonella infections in The Gambia, 2005-2015

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Show simple item record Kwambana-Adams, B. Darboe, S. Nabwera, H. Foster-Nyarko, E. Ikumapayi, U. N. Secka, O. Betts, M. Bradbury, R. Wegmüller, R. Lawal, B. Saha, D. Hossain, M. J. Prentice, A. M. Kampmann, B. Anderson, S. D'Alessandro, U. Antonio, M. 2016-01-29T13:59:58Z 2016-01-29T13:59:58Z 2015
dc.identifier.issn 1058-4838
dc.identifier.doi ://
dc.identifier.other ITG-H16A
dc.identifier.other DPH
dc.identifier.other U-ECMAL
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other Abstract
dc.identifier.other UPD60
dc.description.abstract BACKGROUND: There are large data gaps in the epidemiology of diseases caused by Salmonella enterica in West Africa. Regional surveillance of Salmonella infections is necessary, especially with the emergence and spread of multidrug-resistant clones. METHODS: Data on Salmonella isolated from various clinical specimens from patients from across The Gambia were collected and analyzed retrospectively from 2005 to April 2015. Antibiotic sensitivity testing of Salmonella isolates was performed by disk diffusion method. Serotyping and serogrouping of Salmonella isolates was performed using standard microbiology techniques. RESULTS: Two hundred three Salmonella isolates were isolated from 190 patients: 52% (106/203) from blood and 39% (79/203) from stool specimens. Salmonella was also isolated from urine, aspirates, cerebrospinal fluid, wounds, and abscesses. The prevalence of Salmonella in blood cultures was 0.8% (106/13 905). Of the serotyped salmonellae, 14% (21/152) were Salmonella enterica serovar Typhi, whereas 86% (131/152) were serovars other than Typhi (nontyphoidal Salmonella). Of the 102 typed NTS isolates, 40% (41) were Salmonella enterica serovar Typhimurium, 10% (10) were Salmonella enterica serovar Enteritidis, and 3% (3) were Salmonella enterica serovar Arizonae. Overall, 70% (142/203) of the salmonellae were pansusceptible. Multidrug resistance was found in 4% (9/203) of the isolates, 3 of which were Salmonella Enteritidis. CONCLUSIONS: Salmonellae are associated with a wide spectrum of invasive and noninvasive infections across all ages in The Gambia. There is evidence of multidrug resistance in salmonellae that warrants vigilant monitoring and surveillance. en_US
dc.language English en_US
dc.subject Bacterial diseases en_US
dc.subject Salmonella en_US
dc.subject Salmonella enterica en_US
dc.subject Salmonella typhi en_US
dc.subject Salmonella typhimurium en_US
dc.subject Epidemiology en_US
dc.subject Multidrug resistance en_US
dc.subject Serotyping en_US
dc.subject Serogroups en_US
dc.subject Gambia en_US
dc.subject Africa, West en_US
dc.title Salmonella infections in The Gambia, 2005-2015 en_US
dc.type Article en_US
dc.citation.issue Suppl. 4 en_US
dc.citation.jtitle Clinical Infectious Diseases en_US
dc.citation.volume 61 en_US
dc.citation.pages S354-S362 en_US
dc.citation.jabbreviation Clin Infect Dis en_US

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