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Trypanosoma brucei gambiense spliced leader RNA is a more specific marker for cure of human African trypanosomiasis than T.b. gambiense DNA

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dc.contributor.author Ilboudo, H.
dc.contributor.author Camara, O.
dc.contributor.author Ravel, S.
dc.contributor.author Bucheton, B.
dc.contributor.author Lejon, V.
dc.contributor.author Camara, M.
dc.contributor.author Kabore, J.
dc.contributor.author Jamonneau, V.
dc.contributor.author Deborggraeve, S.
dc.date.accessioned 2016-02-18T12:31:13Z
dc.date.available 2016-02-18T12:31:13Z
dc.date.issued 2015
dc.identifier.issn 0022-1899
dc.identifier.doi http://dx.doi.org/10.1093/infdis/jiv337
dc.identifier.other ITG-BLA
dc.identifier.other DBM
dc.identifier.other U-DIABAC
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other Abstract
dc.identifier.other UPD60
dc.identifier.uri http://hdl.handle.net/10390/8670
dc.description.abstract To assess the efficacy of treatment for human African trypanosomiasis (HAT), accurate tests that can discriminate relapsed from cured patients are needed. We here report the first data that the spliced leader (SL) RNA is a more specific marker for cure of HAT than parasite DNA. In blood samples from 61 cured HAT patients, SL-RNA detection showed specificities between 98.4% and 100%, while DNA detection only 77%. Our proof of concept data shows that SL-RNA detection has high potential as a test of cure. en_US
dc.language English en_US
dc.subject Protozoal diseases en_US
dc.subject Sleeping sickness en_US
dc.subject Trypanosomiasis, African en_US
dc.subject Trypanosoma brucei gambiense en_US
dc.subject Vectors en_US
dc.subject Tsetse flies en_US
dc.subject Glossina morsitans morsitans en_US
dc.subject Treatment en_US
dc.subject Efficacy en_US
dc.subject Relapses en_US
dc.subject Markers en_US
dc.subject Spliced leader en_US
dc.subject RNA en_US
dc.subject DNA en_US
dc.subject Specificity en_US
dc.subject Guinea en_US
dc.subject Africa, West en_US
dc.title Trypanosoma brucei gambiense spliced leader RNA is a more specific marker for cure of human African trypanosomiasis than T.b. gambiense DNA en_US
dc.type Article en_US
dc.citation.issue 12 en_US
dc.citation.jtitle Journal of Infectious Diseases en_US
dc.citation.volume 212 en_US
dc.citation.pages 1996-1998 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/26080371
dc.citation.jabbreviation J Infect Dis en_US


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