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Seasonal variation in haematological and biochemical reference values for healthy young children in The Gambia

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dc.contributor.author Okebe, J.
dc.contributor.author Mwesigwa, J.
dc.contributor.author Agbla, S. C.
dc.contributor.author Sanya-Isijola, F.
dc.contributor.author Abubakar, I.
dc.contributor.author D'Alessandro, U.
dc.contributor.author Jaye, A.
dc.contributor.author Bojang, K.
dc.date.accessioned 2016-03-22T15:41:18Z
dc.date.available 2016-03-22T15:41:18Z
dc.date.issued 2016
dc.identifier.issn 1471-2431
dc.identifier.doi http://dx.doi.org/10.1186/s12887-016-0545-6
dc.identifier.other ITG-H6A
dc.identifier.other DPH
dc.identifier.other U-ECMAL
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other FTA
dc.identifier.other OAJ
dc.identifier.other Abstract
dc.identifier.other UPD61
dc.identifier.uri http://hdl.handle.net/10390/8777
dc.description.abstract BACKGROUND: Haematological and biochemistry reference values for children are important for interpreting clinical and research results however, differences in demography and environment poses a challenge when comparing results. The study defines reference intervals for haematological and biochemistry parameters and examines the effect of seasonality in malaria transmission. METHODS: Blood samples collected from clinically healthy children, aged 12-59 months, in two surveys during the dry and wet season in the Upper River region of The Gambia were processed and the data analysed to generate reference intervals based on the 2.5(th) and 97.5(th) percentiles of the data. RESULTS: Analysis was based on data from 1141 children with median age of 32 months. The mean values for the total white cell count and differentials; lymphocyte, monocyte and neutrophil decreased with increasing age, were lower in males and higher in the wet season survey. However, platelet values declined with age (p < 0.0001). There was no evidence of effect of gender on mean values of AST, ALT, lymphocytes, monocytes, platelets and haemoglobin. CONCLUSION: Mean estimates for haematological and biochemistry reference intervals are affected by age and seasonality in the first five years of life. This consistency is important for harmonisation of reference values for clinical care and interpretation of trial results. en_US
dc.language English en_US
dc.subject Protozoal diseases en_US
dc.subject Malaria en_US
dc.subject Plasmodium falciparum en_US
dc.subject Children en_US
dc.subject Hematology en_US
dc.subject Biochemistry en_US
dc.subject Reference values en_US
dc.subject Seasonal variation en_US
dc.subject White blood cell count en_US
dc.subject Lymphocyte count en_US
dc.subject Monocytes en_US
dc.subject Platelets en_US
dc.subject Gambia en_US
dc.subject Africa, West en_US
dc.title Seasonal variation in haematological and biochemical reference values for healthy young children in The Gambia en_US
dc.type Article-E en_US
dc.citation.issue 5 en_US
dc.citation.jtitle BMC Pediatrics en_US
dc.citation.volume 16 en_US
dc.citation.pages 1-8 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/26754650
dc.citation.jabbreviation BMC Pediatr en_US


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