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Dynamics of nasal carriage of methicillin-resistant Staphylococcus aureus among healthcare workers in a tertiary-care hospital in Peru

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dc.contributor.author Garcia, C.
dc.contributor.author Acuña-Villaorduña, A.
dc.contributor.author Dulanto, A.
dc.contributor.author Vandendriessche, S.
dc.contributor.author Hallin, M.
dc.contributor.author Jacobs, J.
dc.contributor.author Denis, O.
dc.date.accessioned 2016-04-28T15:07:27Z
dc.date.available 2016-04-28T15:07:27Z
dc.date.issued 2016
dc.identifier.issn 0934-9723
dc.identifier.doi http://dx.doi.org/10.1007/s10096-015-2512-9
dc.identifier.other ITG-C6A
dc.identifier.other DCS
dc.identifier.other U-TLM
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other Abstract
dc.identifier.other UPD61
dc.identifier.uri http://hdl.handle.net/10390/8785
dc.description.abstract The study aims were to describe the frequency and dynamics of methicillin-resistant Staphylococcus aureus (MRSA) carriage among healthcare workers (HCWs), and to compare the molecular epidemiology of MRSA isolates from HCWs with those from patients with bacteremia. HCWs were interviewed and three nasal swabs were collected in a hospital in Lima, Peru, during 2009-2010. Consecutive S. aureus blood culture isolates from patients with bacteremia in the same hospital were also collected. SCCmec, multilocus sequence typing (MLST), and spa typing were performed. Persistent carriage was defined if having at least two consecutive cultures grown with S. aureus harboring an identical spa type. Among 172 HCWs included, the proportions of S. aureus and MRSA nasal carriage during first sampling were 22.7 % and 8.7 %, respectively. From 160 HCWs who were sampled three times, 12.5 % (20/160) were persistent S. aureus carriers and 26.9 % (43/160) were intermittent carriers. MRSA carriage among persistent and intermittent S. aureus carriers was 45.0 % (9/20) and 37.2 % (16/43), respectively. Fifty-six S. aureus blood culture isolates were analyzed, and 50 % (n = 28) were MRSA. Multidrug resistant ST5-spa t149-SCCmec I and ST72-spa t148-SCCmec non-typeable were the two most frequent genotypes detected among HCWs (91.7 %, i.e., 22/24 HCW in whom MRSA was isolated in at least one sample) and patients (24/28, 85.7 %). In conclusion, we found high proportions of MRSA among persistent and intermittent S. aureus nasal carriers among HCWs in a hospital in Lima. They belonged to similar genetic lineages as those recovered from patients with bacteremia. en_US
dc.language English en_US
dc.subject Bacterial diseases en_US
dc.subject Occupational diseases en_US
dc.subject Staphylococcus aureus en_US
dc.subject Drug resistance en_US
dc.subject Methicillin en_US
dc.subject Transmission dynamics en_US
dc.subject Frequency en_US
dc.subject Health workers en_US
dc.subject Hospital workers en_US
dc.subject Patients en_US
dc.subject Carriers en_US
dc.subject Associations en_US
dc.subject Peru en_US
dc.subject America, Latin en_US
dc.title Dynamics of nasal carriage of methicillin-resistant Staphylococcus aureus among healthcare workers in a tertiary-care hospital in Peru en_US
dc.type Article en_US
dc.citation.issue 1 en_US
dc.citation.jtitle European Journal of Clinical Microbiology and Infectious Diseases en_US
dc.citation.volume 35 en_US
dc.citation.pages 89-93 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/26515579
dc.citation.jabbreviation Eur J Clin Microbiol Infect Dis en_US


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