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Population genetics of Plasmodium vivax in four rural communities in central Vietnam

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dc.contributor.author Hong, N. V.
dc.contributor.author Delgado-Ratto, C.
dc.contributor.author Thanh, P. V.
dc.contributor.author Van den Eede, P.
dc.contributor.author Guetens, P.
dc.contributor.author Binh, N. T.
dc.contributor.author Phuc, B. Q.
dc.contributor.author Duong, T. T.
dc.contributor.author Van geertruyden, J. P.
dc.contributor.author D'Alessandro, U.
dc.contributor.author Erhart, A.
dc.contributor.author Rosanas-Urgell, A.
dc.date.accessioned 2016-05-18T09:36:46Z
dc.date.available 2016-05-18T09:36:46Z
dc.date.issued 2016
dc.identifier.issn 1935-2727
dc.identifier.doi http://dx.doi.org/10.1371/journal.pntd.0004434
dc.identifier.other ITG-B1B
dc.identifier.other ITG-B4B
dc.identifier.other ITG-B5B
dc.identifier.other ITG-H10A
dc.identifier.other ITG-B11A
dc.identifier.other ITG-BLA
dc.identifier.other MULTI
dc.identifier.other DBM
dc.identifier.other U-MALAR
dc.identifier.other DPH
dc.identifier.other U-ECMAL
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other FTA
dc.identifier.other OAJ
dc.identifier.other Abstract
dc.identifier.other UPD61
dc.identifier.uri http://hdl.handle.net/10390/8802
dc.description.abstract BACKGROUND: The burden of malaria in Vietnam has drastically reduced, prompting the National Malaria Control Program to officially engage in elimination efforts. Plasmodium vivax is becoming increasingly prevalent, remaining a major problem in the country's central and southern provinces. A better understanding of P. vivax genetic diversity and structure of local parasite populations will provide baseline data for the evaluation and improvement of current efforts for control and elimination. The aim of this study was to examine the population genetics and structure of P. vivax isolates from four communities in Tra Leng commune, Nam Tra My district in Quang Nam, Central Vietnam. METHODOLOGY/PRINCIPAL FINDINGS: P. vivax mono infections collected from 234 individuals between April 2009 and December 2010 were successfully analyzed using a panel of 14 microsatellite markers. Isolates displayed moderate genetic diversity (He = 0.68), with no significant differences between study communities. Polyclonal infections were frequent (71.4%) with a mean multiplicity of infection of 1.91 isolates/person. Low but significant genetic differentiation (FST value from -0.05 to 0.18) was observed between the community across the river and the other communities. Strong linkage disequilibrium ([Formula: see text] = 0.113, p < 0.001) was detected across all communities, suggesting gene flow within and among them. Using multiple approaches, 101 haplotypes were grouped into two genetic clusters, while 60.4% of haplotypes were admixed. CONCLUSIONS/SIGNIFICANCE: In this area of Central Vietnam, where malaria transmission has decreased significantly over the past decade, there was moderate genetic diversity and high occurrence of polyclonal infections. Local human populations have frequent social and economic interactions that facilitate gene flow and inbreeding among parasite populations, while decreasing population structure. Findings provide important information on parasites populations circulating in the study area and are relevant to current malaria elimination efforts. en_US
dc.language English en_US
dc.subject Protozoal diseases en_US
dc.subject Malaria en_US
dc.subject Plasmodium vivax en_US
dc.subject Vectors en_US
dc.subject Mosquitoes en_US
dc.subject Anopheles en_US
dc.subject Population genetics en_US
dc.subject Population structure en_US
dc.subject Genetic diversity en_US
dc.subject Polyclonal infections en_US
dc.subject Rural en_US
dc.subject Vietnam en_US
dc.subject Asia, Southeast en_US
dc.title Population genetics of Plasmodium vivax in four rural communities in central Vietnam en_US
dc.type Article-E en_US
dc.citation.issue 2 en_US
dc.citation.jtitle PLoS Neglected Tropical Diseases en_US
dc.citation.volume 10 en_US
dc.citation.pages e0004434 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/26872387
dc.citation.jabbreviation PLoS Negl Trop Dis en_US


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