Institute of Tropical Medicine Antwerp
Foundation of Public Utility

Drug quality analysis through high performance liquid chromatography of isometamidium chloride hydrochloride and diminazene diaceturate purchased from official and unofficial sources in Northern Togo

DSpace/Manakin Repository

Show simple item record

dc.contributor.author Tchamdja, E.
dc.contributor.author Kulo, A. E.
dc.contributor.author Akoda, K.
dc.contributor.author Teko-Agbo, A.
dc.contributor.author Assoumy, A. M.
dc.contributor.author Niang, E. M.
dc.contributor.author Batawui, K.
dc.contributor.author Adomefa, K.
dc.contributor.author Bankole, A. A.
dc.contributor.author Kombiagou, K.
dc.contributor.author Hoppenheit, A.
dc.contributor.author Clausen, P. H.
dc.contributor.author Mattioli, R. C.
dc.contributor.author Peter, R.
dc.contributor.author Napier, G. B.
dc.contributor.author De Deken, R.
dc.contributor.author Marcotty, T.
dc.contributor.author Van Den Abbeele, J.
dc.contributor.author Delespaux, V.
dc.date.accessioned 2016-06-02T14:33:30Z
dc.date.available 2016-06-02T14:33:30Z
dc.date.issued 2016
dc.identifier.issn 0167-5877
dc.identifier.doi http://dx.doi.org/10.1016/j.prevetmed.2016.02.001
dc.identifier.other ITG-B18A
dc.identifier.other ITG-BLA
dc.identifier.other DBM
dc.identifier.other U-VPROT
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other Abstract
dc.identifier.other UPD62
dc.identifier.uri http://hdl.handle.net/10390/8908
dc.description.abstract Trypanocidal drugs remain the most accessible and thus commonly used means of controlling tsetse transmitted animal African trypanosomosis. In Togo, trypanocides are sold on official as well as unofficial markets, but the quality of these trypanocides is undocumented so a drug quality assessment study was conducted from May 2013 to June 2014. Trypanocides supplied by European, Indian and Chinese pharmaceutical companies and sold on official and unofficial markets in Togo were purchased. In total fifty-two trypanocides were obtained, 24 of these samples from official markets and 28 from unofficial markets made up of a total of 36 diminazene diaceturate and 16 isometamidium chloride hydrochloride samples. The samples were analysed in the reference laboratory of the OIE (World Organisation for Animal Health), Laboratory for the Control of Veterinary Medicines (LACOMEV) in Dakar which uses galenic testing and high performance liquid chromatography (HPLC) testing as standard reference analysis methods. The results revealed a high proportion of trypanocides of sub-standard quality on the Togolese market: 40% were non-compliant to these quality reference standards. All of the HPLC non-compliant samples contained lower amounts of active ingredient compared to the concentration specified on the packaging. Non-compliance was higher in samples from the unofficial (53.57%) than from the official markets (25%; p=0.04).The main drug manufacturers, mostly of French origin in the study area, supply quality drugs through the official legal distribution circuit. Products of other origins mostly found on illegal markets present a significantly lower quality. en_US
dc.language English en_US
dc.subject Protozoal diseases en_US
dc.subject Sleeping sickness en_US
dc.subject Trypanosomiasis, African en_US
dc.subject Trypanosoma brucei gambiense en_US
dc.subject Trypanosoma brucei rhodesiense en_US
dc.subject Vectors en_US
dc.subject Tsetse flies en_US
dc.subject Glossina morsitans morsitans en_US
dc.subject Evaluation en_US
dc.subject Performance en_US
dc.subject Drugs en_US
dc.subject Quality assessment en_US
dc.subject Isometamidium chloride en_US
dc.subject Diminazene aceturate en_US
dc.subject Chromatography en_US
dc.subject Togo en_US
dc.subject Africa, West en_US
dc.title Drug quality analysis through high performance liquid chromatography of isometamidium chloride hydrochloride and diminazene diaceturate purchased from official and unofficial sources in Northern Togo en_US
dc.type Article en_US
dc.citation.jtitle Preventive Veterinary Medicine en_US
dc.citation.volume 126 en_US
dc.citation.pages 151-158 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/26907208
dc.citation.jabbreviation Prev Vet Med en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record