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Rodent malaria in the natural host; irradiated sporozoites of Plasmodium berghei induce liver-stage specific immune responses in the natural host Grammomys surdaster and protect immunized Grammomys against P. berghei sporozoite challenge

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dc.contributor.author Chatterjee, S. en_US
dc.contributor.author Ngonseu, E. en_US
dc.contributor.author Van Overmeir, C. en_US
dc.contributor.author Correwyn, A. en_US
dc.contributor.author Druilhe, P. en_US
dc.contributor.author Wéry, M. en_US
dc.date.accessioned 2007-12-06T14:33:15Z
dc.date.available 2007-12-06T14:33:15Z
dc.date.issued 2001 en_US
dc.identifier.issn 0309-3913 en_US
dc.identifier.other ITG-P1A en_US
dc.identifier.other ITG-P2B en_US
dc.identifier.other ITG-P3B en_US
dc.identifier.other ITG-P4B en_US
dc.identifier.other ITG-XLP en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-PROTO en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/92
dc.description.abstract The choice of the host in studying host-parasite interactions is of crucial importance, and the use of a natural host is most appropriate in answering pertinent questions related to human malaria. The Grammomys surdaster is the natural host and reservoir of the rodent malaria parasite Plasmodium berghei. This natural host is difficult to protect by irradiated sporozoite immunization, a situation comparable to what has been observed in humans with P. falciparum. This is in contrast to the complete protection that can be induced in artificial hosts like inbred mice strains. The natural host is highly susceptible to P. berghei hepatic stage infections. Immunization with irradiated sporozoites in Grammomys generates blocked hepatic stage parasites and immunized Grammomys protected upon live sporozoite challenge generate antibody and T cell proliferative responses to these hepatic stages. Associated with proliferation, cytokines are secreted into culture supernatants constituted mainly of Interferon gamma, negligible amounts of TNF-alpha, and no IL-4. Natural host-parasite interactions of Grammomys surdaster-P. berghei can help define the effector mechanism(s) in the Plasmodium falciparum-human interaction. en_US
dc.language English en_US
dc.subject Protozoal diseases en_US
dc.subject Rodent malaria en_US
dc.subject Plasmodium berghei en_US
dc.subject Host-parasite relations en_US
dc.subject Reservoirs en_US
dc.subject Grammomys surdaster en_US
dc.subject Immune response en_US
dc.subject Liver en_US
dc.subject Sporozoites en_US
dc.subject Irradiation en_US
dc.title Rodent malaria in the natural host; irradiated sporozoites of Plasmodium berghei induce liver-stage specific immune responses in the natural host Grammomys surdaster and protect immunized Grammomys against P. berghei sporozoite challenge en_US
dc.type Article en_US
dc.citation.issue Suppl. en_US
dc.citation.jtitle African Journal of Medicine and Medical Sciences en_US
dc.citation.volume 30 en_US
dc.citation.pages 25-33 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/14513935
dc.citation.jabbreviation Afr J Med Med Sci en_US


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