Institute of Tropical Medicine Antwerp
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Origin, distribution, and potential risk factors associated with influenza A virus in swine in two production systems in Guatemala

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Show simple item record Gonzalez-Reiche, A. S. en_US Ramirez, A. L. en_US Muller, M. L. en_US Orellana, D. en_US Sosa, S. M. en_US Ola, P. en_US Paniagua, J. en_US Ortiz, L. en_US Hernandez, J. en_US Cordon-Rosales, C. en_US Perez, D. R. en_US 2017-12-18T12:55:41Z 2017-12-18T12:55:41Z 2017 en_US
dc.identifier.issn 1750-2640 en_US
dc.identifier.doi en_US
dc.identifier.other en_US
dc.identifier.other 44 en_US
dc.identifier.other ITG-B2B; DBM; U-xxx; JIF; DOI; PDF; PMC; Abstract; DSPACE64 en_US
dc.description.abstract BACKGROUND: Guatemala is the country with the largest swine production in Central America; however, evidence of influenza A virus (IAV) in pigs has not been clearly delineated. OBJECTIVES: In this study, we analyzed the presence and spatial distribution of IAV in commercial and backyard swine populations. METHODS: Samples from two nationwide surveys conducted in 2010 and 2011 were tested using virological (rRT-PCR and virus isolation) and serological (ELISA and hemagglutination inhibition) assays to detect IAV. RESULTS: Influenza A virus was detected in 15.7% of the sampled pigs (30.6% of herds) in 2010 and in 11.7% (24.2% of herds) in 2011. The percentage of seropositive pigs was 10.6% (16.1% of herds) and 1.4% (3.1% of herds) for each year, respectively. Three pandemic H1N1 and one seasonal human-like H3N2 viruses were isolated. Antibodies against viruses from different genetic clusters were detected. No reassortant strains with swine viruses were detected. The H3N2 virus was closely related to human viruses that circulated in Central America in 2010, distinct to the most recent human seasonal vaccine lineages. Spatial clusters of rRT-PCR positive herds were detected each year by scan statistics. CONCLUSIONS: Our results demonstrate circulation of IAV throughout Guatemala and identify commercial farms, animal health status, and age as potential risk factors associated with IAV infection and exposure. Detection of human-origin viruses in pigs suggests a role for humans in the molecular epidemiology of IAV in swine in Guatemala and evidences gaps in local animal and human surveillance. en_US
dc.language English en_US
dc.relation.uri en_US
dc.subject Influenza A virus en_US
dc.subject Virology en_US
dc.subject Distribution en_US
dc.subject Viral diseases en_US
dc.subject Zoonoses en_US
dc.subject Animal diseases en_US
dc.subject Pigs en_US
dc.subject Guatemala en_US
dc.subject America-Central en_US
dc.subject America-Latin en_US
dc.title Origin, distribution, and potential risk factors associated with influenza A virus in swine in two production systems in Guatemala en_US
dc.type Article en_US
dc.citation.issue 2 en_US
dc.citation.jtitle Influenza and Other Respiratory Viruses en_US
dc.citation.volume 11 en_US
dc.citation.pages 182-192 en_US
dc.citation.abbreviation Influenza Other Respir Viruses en_US

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