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A longitudinal analysis of the vaginal microbiota and vaginal immune mediators in women from sub-Saharan Africa

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Show simple item record Jespers, V. en_US Kyongo, J. en_US Joseph, S. en_US Hardy, L. en_US Cools, P. en_US Crucitti, T. en_US Mwaura, M. en_US Ndayisaba, G. en_US Delany-Moretlwe, S. en_US Buyze, J. en_US Vanham, G. en_US van de Wijgert, J. H. H. M. en_US 2017-12-18T12:55:43Z 2017-12-18T12:55:43Z 2017 en_US
dc.identifier.issn 2045-2322 en_US
dc.identifier.doi en_US
dc.identifier.other en_US
dc.identifier.other 13 pp. en_US
dc.identifier.other ITG-xxx; MULTI3; DPH; DCS; DBM; U-xxx; OAJ; DOI; PDF; PMC; Abstract; DSPACE64; Check en_US
dc.description.abstract In cross-sectional studies increased vaginal bacterial diversity has been associated with vaginal inflammation which can be detrimental for health. We describe longitudinal changes at 5 visits over 8 weeks in vaginal microbiota and immune mediators in African women. Women (N = 40) with a normal Nugent score at all visits had a stable lactobacilli dominated microbiota with prevailing Lactobacillus iners. Presence of prostate-specific antigen (proxy for recent sex) and being amenorrhoeic (due to progestin-injectable use), but not recent vaginal cleansing, were significantly associated with microbiota diversity and inflammation (controlled for menstrual cycle and other confounders). Women (N = 40) with incident bacterial vaginosis (Nugent 7-10) had significantly lower concentrations of lactobacilli and higher concentrations of Gardnerella vaginalis, Atopobium vaginae, and Prevotella bivia, at the incident visit and when concentrations of proinflammatory cytokines (IL-1beta, IL-12p70) were increased and IP-10 and elafin were decreased. A higher 'composite-qPCR vaginal-health-score' was directly associated with decreased concentrations of proinflammatory cytokines (IL-1alpha, IL-8, IL-12(p70)) and increased IP-10. This longitudinal study confirms the inflammatory nature of vaginal dysbiosis and its association with recent vaginal sex and progestin-injectable use. A potential role for proinflammatory mediators and IP-10 in combination with the vaginal-health-score as predictive biomarkers for vaginal dysbiosis merits further investigation. en_US
dc.language English en_US
dc.relation.uri en_US
dc.subject Vaginal flora en_US
dc.subject Africa-General en_US
dc.title A longitudinal analysis of the vaginal microbiota and vaginal immune mediators in women from sub-Saharan Africa en_US
dc.type Article-E en_US
dc.citation.issue 1 en_US
dc.citation.jtitle Scientific Reports en_US
dc.citation.volume 7 en_US
dc.citation.pages 11974 en_US
dc.citation.abbreviation Sci Rep en_US

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