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Trypanosoma equiperdum: master of disguise or historical mistake?

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Show simple item record Claes, F. en_US Büscher, P. en_US Touratier, L. en_US Goddeeris, B. M. en_US 2007-12-06T14:33:16Z 2007-12-06T14:33:16Z 2005 en_US
dc.identifier.issn 1471-4922 en_US
dc.identifier.other ITG-P1A en_US
dc.identifier.other ITG-P2A en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-SEROL en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other ABSTRACT en_US
dc.description.abstract After 100 years of research, only a small number of laboratory strains of Trypanosoma equiperdum exists, and the history of most of the strains is unknown. No definitive diagnosis of dourine can be made at the serological or molecular level. Only clinical signs are pathognomonic and international screening relies on an outdated cross-reactive serological test (the complement-fixation test) from 1915, resulting in serious consequences at the practical level. Despite many characterization attempts, no clear picture has emerged of the position of T. equiperdum within the Trypanozoon group. In this article, we highlight the controversies that exist regarding T. equiperdum, and the overlap that occurs with Trypanosoma evansi and Trypanosoma brucei brucei. By revisiting the published data, from the early decades of discovery to the recent serological- and molecular-characterization studies, a new hypothesis arises in which T. equiperdum no longer exists as a separate species and in which current strains can be divided into T. evansi (the historical mistake) and Trypanosoma brucei equiperdum (the master of disguise). Hence, dourine is a disease caused by specific host immune responses to a T. b. equiperdum or T. evansi infection. en_US
dc.language English en_US
dc.publisher Cell Press en_US
dc.subject Protozoal diseases en_US
dc.subject Trypanosomiasis en_US
dc.subject Dourine en_US
dc.subject Characterization en_US
dc.subject Trypanosoma equiperdum en_US
dc.subject Trypanosoma evansi en_US
dc.subject Trypanosoma brucei brucei en_US
dc.title Trypanosoma equiperdum: master of disguise or historical mistake? en_US
dc.type Article en_US
dc.citation.issue 7 en_US
dc.citation.jtitle Trends in Parasitology en_US
dc.citation.volume 21 en_US
dc.citation.pages 316-321 en_US St. Louis en_US
dc.citation.jabbreviation Trends Parasitol en_US

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