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The FAS-670 AA genotype is associated with high proviral load in Peruvian HAM/TSP patients

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dc.contributor.author Rosado, J. en_US
dc.contributor.author Morales, S. en_US
dc.contributor.author Lopez, G. en_US
dc.contributor.author Clark, D. en_US
dc.contributor.author Verdonck, K. en_US
dc.contributor.author Gotuzzo, E. en_US
dc.contributor.author Van Camp, G. en_US
dc.contributor.author Talledo, M. en_US
dc.date.accessioned 2017-12-18T12:55:49Z
dc.date.available 2017-12-18T12:55:49Z
dc.date.issued 2017 en_US
dc.identifier.issn 0146-6615 en_US
dc.identifier.doi http://dx.doi.org/10.1002/jmv.24681 en_US
dc.identifier.other http://lib.itg.be/pdf/itg/2017/2017jmvi0726.pdf en_US
dc.identifier.other ITG-H5A; DPH; U-ECTD; JIF; DOI; PDF; Abstract; DSPACE64 en_US
dc.identifier.uri http://hdl.handle.net/10390/9624
dc.description.abstract BACKGROUND: Human T-lymphotropic virus 1 (HTLV-1) is the etiologic agent of the HTLV-I-Associated Myelopathy-Tropical Spastic Paraparesis (HAM/TSP). Apoptosis is a mechanism of defense elicited by many triggers, including cross-linking of the FAS receptor expressed in viruses-infected cells, and the ligand FASL presented by T-cytotoxic cells. Since HAM/TSP has been associated with high levels of proviral load (PVL), we hypothesized that certain genotypes of single-nucleotide polymorphisms (SNPs) associated with a decreased protein expression of FAS and FASL could be risk factors for this disease. Three SNPs: FAS-670A/G (rs1800682), FAS-1377G/A (rs2234767) and FASL-844C/T (rs763110), were analyzed in 73 HAM/TSP patients and 143 HTLV-1 asymptomatic carriers. Ancestry informative markers were used to adjust for ethnicity through a principal component analysis. Gender, age, PVL and the first three principal components were used as covariates. RESULTS: The FAS/FASL genotype distribution was not associated with HAM/TSP presence (p > 0.05). The FAS-670 AA genotype was associated with high PVL in comparison to FAS-670 GG in HAM/TSP patients (p = 0.015), while in asymptomatic carriers low levels of PVL were observed (p > 0.05). CONCLUSIONS: Our findings suggest that rs1800682, rs2234767, and rs763110 genotypes are not associated with the presence of HAM/TSP, but that the FAS-670 AA genotype can promote higher PVL values in HAM/TSP patients. This article is protected by copyright. All rights reserved. en_US
dc.language English en_US
dc.relation.uri http://www.ncbi.nlm.nih.gov/pubmed/27603042 en_US
dc.subject HTLV-1 en_US
dc.subject Viral diseases en_US
dc.subject Viral load en_US
dc.subject Peru en_US
dc.subject America-Latin en_US
dc.title The FAS-670 AA genotype is associated with high proviral load in Peruvian HAM/TSP patients en_US
dc.type Article en_US
dc.citation.issue 4 en_US
dc.citation.jtitle Journal of Medical Virology en_US
dc.citation.volume 89 en_US
dc.citation.pages 726-731 en_US
dc.citation.abbreviation J Med Virol en_US


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