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A tuberculosis nationwide prevalence survey in Gambia, 2012

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dc.contributor.author Adetifa, I. M. en_US
dc.contributor.author Kendall, L. en_US
dc.contributor.author Bashorun, A. en_US
dc.contributor.author Linda, C. en_US
dc.contributor.author Omoleke, S. en_US
dc.contributor.author Jeffries, D. en_US
dc.contributor.author Maane, R. en_US
dc.contributor.author Alorse, B. D. en_US
dc.contributor.author Alorse, W. D. en_US
dc.contributor.author Okoi, C. B. en_US
dc.contributor.author Mlaga, K. D. en_US
dc.contributor.author Kinteh, M. A. en_US
dc.contributor.author Donkor, S. en_US
dc.contributor.author de Jong, B. C. en_US
dc.contributor.author Antonio, M. en_US
dc.contributor.author D'Alessandro, U. en_US
dc.date.accessioned 2017-12-18T12:55:55Z
dc.date.available 2017-12-18T12:55:55Z
dc.date.issued 2016 en_US
dc.identifier.issn 0042-9686 en_US
dc.identifier.doi http://dx.doi.org/10.2471/BLT.14.151670 en_US
dc.identifier.other http://lib.itg.be/pdf/itg/2016/2016bwho0433.pdf en_US
dc.identifier.other 22 en_US
dc.identifier.other ITG-B14A; ITG-NLH; DBM; U-MYCOB; JIF; DOI; PDF; OAJ; Abstract, DSPACE63 en_US
dc.identifier.uri http://hdl.handle.net/10390/9703
dc.description.abstract OBJECTIVE: To estimate the population prevalence of active pulmonary tuberculosis in Gambia. METHODS: Between December 2011 and January 2013, people aged >/= 15 years participating in a nationwide, multistage cluster survey were screened for active pulmonary tuberculosis with chest radiography and for tuberculosis symptoms. For diagnostic confirmation, sputum samples were collected from those whose screening were positive and subjected to fluorescence microscopy and liquid tuberculosis cultures. Multiple imputation and inverse probability weighting were used to estimate tuberculosis prevalence. FINDINGS: Of 100 678 people enumerated, 55 832 were eligible to participate and 43 100 (77.2%) of those participated. A majority of participants (42 942; 99.6%) were successfully screened for symptoms and by chest X-ray. Only 5948 (13.8%) were eligible for sputum examination, yielding 43 bacteriologically confirmed, 28 definite smear-positive and six probable smear-positive tuberculosis cases. Chest X-ray identified more tuberculosis cases (58/69) than did symptoms alone (43/71). The estimated prevalence of smear-positive and bacteriologically confirmed pulmonary tuberculosis were 90 (95% confidence interval, CI: 53-127) and 212 (95% CI: 152-272) per 100 000 population, respectively. Tuberculosis prevalence was higher in males (333; 95% CI: 233-433) and in the 35-54 year age group (355; 95% CI: 219-490). CONCLUSION: The burden of tuberculosis remains high in Gambia but lower than earlier estimates of 490 per 100 000 population in 2010. Less than half of all cases would have been identified based on smear microscopy results alone. Successful control efforts will require interventions targeting men, increased access to radiography and more accurate, rapid diagnostic tests. en_US
dc.language English en_US
dc.relation.uri http://www.ncbi.nlm.nih.gov/pubmed/27274595 en_US
dc.subject Bacterial diseases en_US
dc.subject Pulmonary en_US
dc.subject Tuberculosis en_US
dc.subject Mycobacterium tuberculosis en_US
dc.subject Prevalence en_US
dc.subject National health en_US
dc.subject Mass screening en_US
dc.subject Mass campaigns en_US
dc.subject Radiography en_US
dc.subject Symptoms en_US
dc.subject Sputum smear microscopy en_US
dc.subject Gender en_US
dc.subject Age en_US
dc.subject Gambia en_US
dc.subject Africa-West en_US
dc.title A tuberculosis nationwide prevalence survey in Gambia, 2012 en_US
dc.type Article en_US
dc.citation.issue 6 en_US
dc.citation.jtitle Bulletin of the World Health Organization en_US
dc.citation.volume 94 en_US
dc.citation.pages 433-441 en_US
dc.citation.abbreviation Bull World Health Organ en_US


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