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Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

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dc.contributor.author Stucki, D. en_US
dc.contributor.author Brites, D. en_US
dc.contributor.author Jeljeli, L. en_US
dc.contributor.author Coscolla, M. en_US
dc.contributor.author Liu, Q. en_US
dc.contributor.author Trauner, A. en_US
dc.contributor.author Fenner, L. en_US
dc.contributor.author Rutaihwa, L. en_US
dc.contributor.author Borrell, S. en_US
dc.contributor.author Luo ,T. en_US
dc.contributor.author Gao, Q. en_US
dc.contributor.author Kato-Maeda, M. en_US
dc.contributor.author Ballif, M. en_US
dc.contributor.author Egger, M. en_US
dc.contributor.author Macedo, R. en_US
dc.contributor.author Mardassi, H. en_US
dc.contributor.author Moreno, M. en_US
dc.contributor.author Vilanova, G. T. en_US
dc.contributor.author Fyfe, J. en_US
dc.contributor.author Globan, M. en_US
dc.contributor.author Thomas, J. en_US
dc.contributor.author Jamieson, F. en_US
dc.contributor.author Guthrie, J. L. en_US
dc.contributor.author Asante-Poku, A. en_US
dc.contributor.author Yeboah-Manu, D. en_US
dc.contributor.author Wampande, E. en_US
dc.contributor.author Ssengooba, W. en_US
dc.contributor.author Joloba, M. en_US
dc.contributor.author Boom, W. H. en_US
dc.contributor.author Basu, I. en_US
dc.contributor.author Bower, J. en_US
dc.contributor.author Saraiva, M. en_US
dc.contributor.author Vasconcellos, S. E. en_US
dc.contributor.author Suffys, P. en_US
dc.contributor.author Koch, A. en_US
dc.contributor.author Wilkinson, R. en_US
dc.contributor.author Gail-Bekker, L. en_US
dc.contributor.author Malla, B. en_US
dc.contributor.author Ley, S. D. en_US
dc.contributor.author Beck, H. P. en_US
dc.contributor.author de Jong, B. C. en_US
dc.contributor.author Toit, K. en_US
dc.contributor.author Sanchez-Padilla,E. en_US
dc.contributor.author Bonnet, M. en_US
dc.contributor.author Gil-Brusola, A. en_US
dc.contributor.author Frank, M. en_US
dc.contributor.author Penlap Beng, V. N. en_US
dc.contributor.author Eisenach, K. en_US
dc.contributor.author Alani, I. en_US
dc.contributor.author Ndung'u, P. W. en_US
dc.contributor.author Revathi, G. en_US
dc.contributor.author Gehre, F. en_US
dc.contributor.author Akter, S. en_US
dc.contributor.author Ntoumi, F. en_US
dc.contributor.author Stewart-Isherwood, L. en_US
dc.contributor.author Ntinginya, N. E. en_US
dc.contributor.author Rachow, A. en_US
dc.contributor.author Hoelscher, M. en_US
dc.contributor.author Cirillo, D. M. en_US
dc.contributor.author Skenders, G. en_US
dc.contributor.author Hoffner, S. en_US
dc.contributor.author Bakonyte, D. en_US
dc.contributor.author Stakenas, P. en_US
dc.contributor.author Diel, R. en_US
dc.contributor.author Crudu, V. en_US
dc.contributor.author Moldovan, O. en_US
dc.contributor.author Al-Hajoj, S. en_US
dc.contributor.author Otero, L. en_US
dc.contributor.author Barletta, F. en_US
dc.contributor.author Carter, E. J. en_US
dc.contributor.author Diero, L. en_US
dc.contributor.author Supply, P. en_US
dc.contributor.author Comas, I. en_US
dc.contributor.author Niemann, S. en_US
dc.contributor.author Gagneux, S. en_US
dc.date.accessioned 2017-12-18T12:56:07Z
dc.date.available 2017-12-18T12:56:07Z
dc.date.issued 2016 en_US
dc.identifier.issn 1061-4036 en_US
dc.identifier.doi http://dx.doi.org/10.1038/ng.3704 en_US
dc.identifier.other http://lib.itg.be/pdf/itg/2016/2016ngen1535.pdf en_US
dc.identifier.other ITG-B41A; ITG-B52A; DBM; U-MYCOB; JIF; DOI; PDF; Abstract; DSPACE64 en_US
dc.identifier.uri http://hdl.handle.net/10390/9889
dc.description.abstract Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration. en_US
dc.language English en_US
dc.relation.uri http://www.ncbi.nlm.nih.gov/pubmed/27798628 en_US
dc.subject Mycobacterium tuberculosis en_US
dc.subject Bacteriology en_US
dc.subject Lineages en_US
dc.title Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages en_US
dc.type Article en_US
dc.citation.issue 12 en_US
dc.citation.jtitle Nature Genetics en_US
dc.citation.volume 48 en_US
dc.citation.pages 1535-1543 en_US
dc.citation.abbreviation Nat Genet en_US


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