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Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

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Show simple item record Stucki, D. en_US Brites, D. en_US Jeljeli, L. en_US Coscolla, M. en_US Liu, Q. en_US Trauner, A. en_US Fenner, L. en_US Rutaihwa, L. en_US Borrell, S. en_US Luo ,T. en_US Gao, Q. en_US Kato-Maeda, M. en_US Ballif, M. en_US Egger, M. en_US Macedo, R. en_US Mardassi, H. en_US Moreno, M. en_US Vilanova, G. T. en_US Fyfe, J. en_US Globan, M. en_US Thomas, J. en_US Jamieson, F. en_US Guthrie, J. L. en_US Asante-Poku, A. en_US Yeboah-Manu, D. en_US Wampande, E. en_US Ssengooba, W. en_US Joloba, M. en_US Boom, W. H. en_US Basu, I. en_US Bower, J. en_US Saraiva, M. en_US Vasconcellos, S. E. en_US Suffys, P. en_US Koch, A. en_US Wilkinson, R. en_US Gail-Bekker, L. en_US Malla, B. en_US Ley, S. D. en_US Beck, H. P. en_US de Jong, B. C. en_US Toit, K. en_US Sanchez-Padilla,E. en_US Bonnet, M. en_US Gil-Brusola, A. en_US Frank, M. en_US Penlap Beng, V. N. en_US Eisenach, K. en_US Alani, I. en_US Ndung'u, P. W. en_US Revathi, G. en_US Gehre, F. en_US Akter, S. en_US Ntoumi, F. en_US Stewart-Isherwood, L. en_US Ntinginya, N. E. en_US Rachow, A. en_US Hoelscher, M. en_US Cirillo, D. M. en_US Skenders, G. en_US Hoffner, S. en_US Bakonyte, D. en_US Stakenas, P. en_US Diel, R. en_US Crudu, V. en_US Moldovan, O. en_US Al-Hajoj, S. en_US Otero, L. en_US Barletta, F. en_US Carter, E. J. en_US Diero, L. en_US Supply, P. en_US Comas, I. en_US Niemann, S. en_US Gagneux, S. en_US 2017-12-18T12:56:07Z 2017-12-18T12:56:07Z 2016 en_US
dc.identifier.issn 1061-4036 en_US
dc.identifier.doi en_US
dc.identifier.other en_US
dc.identifier.other ITG-B41A; ITG-B52A; DBM; U-MYCOB; JIF; DOI; PDF; Abstract; DSPACE64 en_US
dc.description.abstract Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration. en_US
dc.language English en_US
dc.relation.uri en_US
dc.subject Mycobacterium tuberculosis en_US
dc.subject Bacteriology en_US
dc.subject Lineages en_US
dc.title Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages en_US
dc.type Article en_US
dc.citation.issue 12 en_US
dc.citation.jtitle Nature Genetics en_US
dc.citation.volume 48 en_US
dc.citation.pages 1535-1543 en_US
dc.citation.abbreviation Nat Genet en_US

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