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Trypanosoma brucei parasites occupy and functionally adapt to the adipose tissue in mice

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Show simple item record Trindade, S. en_US Rijo-Ferreira, F. en_US Carvalho, T. en_US Pinto-Neves, D. en_US Guegan, F. en_US Aresta-Branco, F. en_US Bento, F. en_US Young, S. A. en_US Pinto, A. en_US Van Den Abbeele, J. en_US Ribeiro, R. M. en_US Dias, S. en_US Smith, T. K. en_US Figueiredo, L. M. en_US 2017-12-18T12:56:08Z 2017-12-18T12:56:08Z 2016 en_US
dc.identifier.issn 1931-3128 en_US
dc.identifier.doi en_US
dc.identifier.other en_US
dc.identifier.other 36 en_US
dc.identifier.other ITG-B10A; DBM; U-VPROT; JIF; DOI; PDF; DOI; Abstract; DSPACE63 en_US
dc.description.abstract Trypanosoma brucei is an extracellular parasite that causes sleeping sickness. In mammalian hosts, trypanosomes are thought to exist in two major niches: early in infection, they populate the blood; later, they breach the blood-brain barrier. Working with a well-established mouse model, we discovered that adipose tissue constitutes a third major reservoir for T. brucei. Parasites from adipose tissue, here termed adipose tissue forms (ATFs), can replicate and were capable of infecting a naive animal. ATFs were transcriptionally distinct from bloodstream forms, and the genes upregulated included putative fatty acid beta-oxidation enzymes. Consistent with this, ATFs were able to utilize exogenous myristate and form beta-oxidation intermediates, suggesting that ATF parasites can use fatty acids as an external carbon source. These findings identify the adipose tissue as a niche for T. brucei during its mammalian life cycle and could potentially explain the weight loss associated with sleeping sickness. en_US
dc.language English en_US
dc.relation.uri en_US
dc.subject Protozoal diseases en_US
dc.subject Sleeping sickness en_US
dc.subject Trypanosomiasis-African en_US
dc.subject Trypanosoma brucei en_US
dc.subject Vectors en_US
dc.subject Tsetse flies en_US
dc.subject Glossina morsitans morsitans en_US
dc.subject Reservoirs en_US
dc.subject Adipose tissue en_US
dc.subject Mouse test en_US
dc.subject Replication en_US
dc.subject Fatty acids en_US
dc.subject Heterogeneity en_US
dc.subject Transcriptome analysis en_US
dc.subject Metabolic mechanisms en_US
dc.subject Adaptation en_US
dc.title Trypanosoma brucei parasites occupy and functionally adapt to the adipose tissue in mice en_US
dc.type Article en_US
dc.citation.issue 6 en_US
dc.citation.jtitle Cell Host and Microbe en_US
dc.citation.volume 19 en_US
dc.citation.pages 837-848 en_US
dc.citation.abbreviation Cell Host Microbe en_US

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