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Proteomic analysis of Taenia solium metacestode excretion-secretion proteins

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dc.contributor.author Victor, B. en_US
dc.contributor.author Kanobana, K. en_US
dc.contributor.author Gabriël, S. en_US
dc.contributor.author Polman, K. en_US
dc.contributor.author Deckers, N. en_US
dc.contributor.author Dorny, P. en_US
dc.contributor.author Deelder, A. M. en_US
dc.contributor.author Palmblad, M. en_US
dc.date.accessioned 2017-12-18T12:56:11Z
dc.date.available 2017-12-18T12:56:11Z
dc.date.issued 2012 en_US
dc.identifier.issn 1615-9853 en_US
dc.identifier.doi http://dx.doi.org/10.1002/pmic.201100496 en_US
dc.identifier.other http://lib.itg.be/pdf/itg/2012/2012prot1860.pdf en_US
dc.identifier.other 57 en_US
dc.identifier.other ITG-B1A; ITG-B2B; ITG-B3A; ITG-B4A; ITG-B6A; DBM; U-VHELM; U-MHELM; JIF; DOI; PDF; Abstract; DSPACE64 en_US
dc.identifier.uri http://hdl.handle.net/10390/9951
dc.description.abstract The metacestode larval stage of Taenia solium is the causal agent of a zoonotic disease called cysticercosis. The disease has an important impact on pork trade (due to porcine cysticercosis) and public health (due to human neurocysticercosis). In order to improve the current diagnostic tools and to get a better understanding of the interaction between T. solium metacestodes and their host, there is a need for more information about the proteins that are released by the parasite. In this study, we used protein sequences from different helminths, 1-D gel electrophoresis, reversed-phase liquid chromatography, and tandem mass spectrometry to analyze the excretion-secretion proteins produced by T. solium metacestodes from infected pigs. This is the first report of the T. solium metacestode excretion-secretion proteome. We report 76 proteins including 27 already described T. solium proteins, 17 host proteins and 32 proteins likely to be of T. solium origin, but identified using sequences from other helminths. en_US
dc.language English en_US
dc.publisher Proteomics en_US
dc.relation.uri http://www.ncbi.nlm.nih.gov/pubmed/22623400 en_US
dc.subject Helminthic diseases en_US
dc.subject Cysticercosis en_US
dc.subject Taenia solium en_US
dc.subject Echinococcus multilocularis en_US
dc.subject Pigs en_US
dc.subject Metacestodes en_US
dc.subject Proteomics en_US
dc.subject Mass spectrometry en_US
dc.subject Proteins en_US
dc.subject Sequencing en_US
dc.subject Zambia en_US
dc.subject Africa-Southern en_US
dc.subject Peru en_US
dc.subject America-Latin en_US
dc.title Proteomic analysis of Taenia solium metacestode excretion-secretion proteins en_US
dc.type Article en_US
dc.citation.issue 11 en_US
dc.citation.volume 12 en_US
dc.citation.pages 1860 en_US
dc.citation.abbreviation Proteomics en_US


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